NCT07331298 Apparent Diffusion Coefficient of the Intervertebral Disc in Children: Pilot Study
| NCT ID | NCT07331298 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Limoges |
| Condition | Scoliosis Idiopathic |
| Study Type | OBSERVATIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-01-05 |
| Primary Completion | 2028-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 60 participants in total. It began in 2026-01-05 with a primary completion date of 2028-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The pathophysiology of adolescent idiopathic scoliosis is unknown. This pathology develops from 10-11 years of age and progresses until skeletal maturity, or even adulthood for the most severe forms. Current knowledge is limited as to its origin on the one hand and the evolutionary nature of scoliosis on the other. The mechanical parameters of the intervertebral disc are incompletely known from the deep location of this organ, its fragile nature in vivo and its susceptibility to desiccation during ex-vivo analysis. To complete our knowledge of the mechanical parameters of the intervertebral disc of scoliotic and non-scoliotic children, we are proposing an in vivo, non-invasive and non-irradiating study carried out in children who are the main target of this pathology. The objective of this work is to characterize the diffusion parameters (apparent diffusion coefficient ADC) of the intervertebral disc in vivo, in a non-invasive and non-irradiating manner by magnetic resonance imaging in children and adolescents. As this measurement has not been carried out in children and adolescents, we want to perform these MRI scans in children free from scoliosis and carriers of scoliosis.
Eligibility Criteria
Inclusion Criteria: * age: patients between 8 and 16 years old * Children undergoing magnetic resonance imaging of the lumbar or spinal region as part of their routine care * Scoliotic: spinal deformity characterized by a hump on clinical examination and a radiological deformation in the coronal plane greater than 10 ° with no etiology found (idiopathic) * Healthy: no hump on clinical examination, walking patients (level 1 and 2 of the global motor function classification system) Exclusion Criteria: * existence of medullary and vertebral pathology other than scoliosis, history of disc or vertebral infection (spondylo-discitis) on examination, neuro-ectodermal pathology * behavioral disturbances incompatible with the performance of the magnetic resonance imaging examination. * Refusal of participation. * Thoracic scoliosis
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07331298 clinical trial?
This trial is open to participants of all sexes, aged 8 Years or older, up to 16 Years, studying Scoliosis Idiopathic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07331298 currently recruiting?
Yes, NCT07331298 is actively recruiting participants. Contact the research team at quentin.ballouhey@chu-limoges.fr for enrollment information.
Where is the NCT07331298 trial being conducted?
This trial is being conducted at Limoges, France, Toulouse, France.
Who is sponsoring the NCT07331298 clinical trial?
NCT07331298 is sponsored by University Hospital, Limoges. The trial plans to enroll 60 participants.