NCT07181564 Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
| NCT ID | NCT07181564 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University General Hospital of Patras |
| Condition | Magnesium Sulfate |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2025-09-11 |
| Primary Completion | 2026-02-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2025-09-11 with a primary completion date of 2026-02-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.
Eligibility Criteria
Inclusion Criteria : Adult patients (≥18 years old). Scheduled for F.E.S.S (Functional endoscopic sinus surgery ) under general anesthesia. Able to provide informed consent Exclusion Criteria: Emergency surgery. ASA physical status IV-V. Severe hepatic or renal dysfunction. Known allergy or contraindication to study drugs. Pregnant or lactating women. unable to provide informed consent Patients unwilling or unable to provide consent.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07181564 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Magnesium Sulfate. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07181564 currently recruiting?
Yes, NCT07181564 is actively recruiting participants. Contact the research team at rizsotiria@gmail.com for enrollment information.
Where is the NCT07181564 trial being conducted?
This trial is being conducted at Pátrai, Greece.
Who is sponsoring the NCT07181564 clinical trial?
NCT07181564 is sponsored by University General Hospital of Patras. The trial plans to enroll 150 participants.