NCT07577609 AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
| NCT ID | NCT07577609 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Galway |
| Condition | Coronary Artery Disease (CAD) |
| Study Type | OBSERVATIONAL |
| Enrollment | 10,000 participants |
| Start Date | 2022-12-21 |
| Primary Completion | 2032-12-21 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 10,000 participants in total. It began in 2022-12-21 with a primary completion date of 2032-12-21.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated cardiac CT. The main questions it aims to answer are: * Can AI-enhanced cardiac CT accurately assess cardiovascular risk in a real-world adult population? * How do CT-derived plaque characteristics correlate with clinical, biochemical, and lifestyle risk factors? Researchers will compare subgroups (e.g., patients with different risk profiles, biomarkers, or imaging findings, and a subset undergoing OCT imaging) to see if differences in imaging and clinical parameters are associated with cardiovascular risk and plaque vulnerability. Participants will: * Provide informed consent and medical history/demographic information * Undergo blood sampling for cardiovascular and metabolic biomarkers * Have a resting ECG performed * Complete a detailed lifestyle and health questionnaire * Receive a non-invasive cardiac CT scan interpreted by an expert * Potentially receive heart rate-lowering medication (e.g., metoprolol) if required for imaging quality * Be referred for further clinical evaluation if clinically indicated 
Eligibility Criteria
Inclusion Criteria: * Adults aged ≥18 years * Undergoing clinically indicated cardiac CT * Able and willing to provide informed consent Exclusion Criteria: * History of malignancy * Abnormal renal function (e.g., eGFR or serum creatinine outside reference range) * Contraindications to iodinated contrast agents or CT imaging
Contact & Investigator
Faisal Sharif, MBBS, PhD, FRCPI, FESC, FACC
PRINCIPAL INVESTIGATOR
University of Galway
Frequently Asked Questions
Who can join the NCT07577609 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Artery Disease (CAD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07577609 currently recruiting?
Yes, NCT07577609 is actively recruiting participants. Contact the research team at faisal.sharif@universityofgalway.ie for enrollment information.
Where is the NCT07577609 trial being conducted?
This trial is being conducted at Galway, Ireland.
Who is sponsoring the NCT07577609 clinical trial?
NCT07577609 is sponsored by University of Galway. The principal investigator is Faisal Sharif, MBBS, PhD, FRCPI, FESC, FACC at University of Galway. The trial plans to enroll 10,000 participants.