| NCT ID | NCT07179107 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Arizona State University |
| Condition | Dehydration |
| Study Type | INTERVENTIONAL |
| Enrollment | 144 participants |
| Start Date | 2025-09-29 |
| Primary Completion | 2028-07-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 144 participants in total. It began in 2025-09-29 with a primary completion date of 2028-07-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Cardiovascular diseases (CVD) are the leading cause of death in middle- and high-income countries, according to data from the World Health Organization (WHO). Epidemiological studies have associated low water intake and underhydration with diabetes, chronic kidney disease, and an increased risk of CVD. Similarly, the prevalence of chronic metabolic dysfunction is increasing dramatically worldwide, becoming both a significant public health concern and a global economic burden. Reports from the WHO indicate that the number of people with diabetes worldwide has risen from 108 million in 1980 to 422 million in 2014, representing 8.5% of adults. Therefore, there is an urgent need to identify modifiable risk factors that could help prevent metabolic dysfunction and mitigate the epidemic of type 2 diabetes (T2D). Evidence suggests that the hormone arginine vasopressin (AVP) may play a key role. AVP is the primary hormone responsible for regulating body fluid balance; however, increased AVP secretion, such as under conditions of low water intake, appears to be a risk factor for developing diabetes. Increasing water intake may represent a simple and cost-effective way to improve glucose regulation and cardiovascular health. However, many individuals do not prefer drinking plain water, and although beverages with high sugar content may promote greater fluid intake, they also contribute additional calories that can negatively impact body weight and overall health. Thus, the central research question of this study is whether improving hydration with non-sugar-sweetened beverages can provide equivalent benefits for hydration and health outcomes in adults. Aim 1: To explore the association between habitual fluid intake and fluid preferences (water and non-sugar-sweetened beverages), hydration biomarkers, and health outcomes in normal-weight and obese adults. Aim 2: To compare the impact of increased total water intake, provided as plain water or non-sugar-sweetened beverages, on hydration, cardiovascular health, and glucose regulation in normal-weight and obese adults.
Eligibility Criteria
Inclusion Criteria: * BMI 18.5-24.9 or 30.0-39.9 kg/m2 * HbA1c ≤7% * Age 20-65 y * available for 8 consecutive weeks same day and time Exclusion Criteria: * Diabetes * HbA1c \>7% BMI ≤18.5, BMI of 25 to \<30, or ≥ 40 kg/m2 * night shifting work * losing or gaining weight during the last 2 months (\>5 lbs. fluctuation) * thyroid medication * bariatric surgery * Habitual strenuous exercise (\>120 min/week) Strenuous exercise is defined as activities that take hard physical effort and make you breathe much harder than normal. * Construction and other workers that spend signifant portion of their work day outdoors * Commuting by bicycle * Eating disorders * Use of aspirin during the duration of the study * Cancer * Renal disease (including kidney stones or recurrent urinary track infections * Hepatic disease * Cardiac conditions * Current infection requiring medication * Chronic, contagious, infectious diseases such as tuberculosis, Hepatitis A, B, C, or HIV * Medication that could affect appetite or body weight regulation * GLP1-RA medication * Anti-depressent SSRI medication * Testosterone replacement therapy * Participating in another study at the same time * Unable to abstain from alcohol during the study * Unable to limit caffeinated beverage intake to 1 cup per day * Donated blood during the past two months * Uneasibly acessable veins * Does not have smart phone
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07179107 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 65 Years, studying Dehydration. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07179107 currently recruiting?
Yes, NCT07179107 is actively recruiting participants. Contact the research team at hydrate.study@gmail.com for enrollment information.
Where is the NCT07179107 trial being conducted?
This trial is being conducted at Phoenix, United States, Phoenix, United States.
Who is sponsoring the NCT07179107 clinical trial?
NCT07179107 is sponsored by Arizona State University. The trial plans to enroll 144 participants.