NCT05386134 Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders
| NCT ID | NCT05386134 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The Hospital for Sick Children |
| Condition | Genetic Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 200 participants |
| Start Date | 2022-06-13 |
| Primary Completion | 2032-06-13 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 200 participants in total. It began in 2022-06-13 with a primary completion date of 2032-06-13.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders. The study would use adaptive optics (AO) technology to assist in-vivo visualization of these retinal structures and ascertain changes from normal. Further, by using the AO imaging in patients before and after treatments, this study aims to better understand the effect of various interventions and develop AO as an outcome measure in various retinal disorders.
Eligibility Criteria
Inclusion Criteria: 1. Consent provided 2. Aged 5 - 70 years 3. Diagnosed with well documented retinal disorder Control group Inclusion Criteria: 1. Subjects aged 5 years - 70 years with normal eye examination. 2. Patients with strabismus and otherwise normal visual acuity and eye examination 3. Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye. Exclusion Criteria: 1. Inability of the subject to maintain a stable position while seated 2. Uncontrolled nystagmus, trembling or movements of the eyes or the head 3. Presence of cataract or any opacity in the front of the eye that obscures retinal imaging 4. Any general disease such neurological disease which could affect vision and the retina. 5. History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy 6. High refractive errors (\> +15D or \< -15D) that cannot be corrected by the adaptive optics system. 7. Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect 8. Patients who are aphakic after cataract surgery
Contact & Investigator
Ajoy Vincent, MS
PRINCIPAL INVESTIGATOR
Associate Professor
Frequently Asked Questions
Who can join the NCT05386134 clinical trial?
This trial is open to participants of all sexes, aged 5 Years or older, up to 70 Years, studying Genetic Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05386134 currently recruiting?
Yes, NCT05386134 is actively recruiting participants. Contact the research team at ajoy.vincent@sickkids.ca for enrollment information.
Where is the NCT05386134 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT05386134 clinical trial?
NCT05386134 is sponsored by The Hospital for Sick Children. The principal investigator is Ajoy Vincent, MS at Associate Professor. The trial plans to enroll 200 participants.