NCT07300384 Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure
| NCT ID | NCT07300384 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Valencia |
| Condition | Severe Knee Osteoarthritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 45 participants |
| Start Date | 2026-02-25 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 45 participants in total. It began in 2026-02-25 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.
Eligibility Criteria
Inclusion Criteria: * Age between 50 and 85 years * Diagnosis of severe gonarthrosis according to the clinical and radiographic criteria of the American College of Rheumatology guidelines. * On the waiting list for unilateral total knee replacement (TKR) surgery Exclusion Criteria: * Pain in the contralateral leg with an intensity ≥80/100 mm on the visual analog scale (VAS) during daily activities. * Previous hip or knee replacement surgery and osteotomy within the last year. * Autoimmune arthritis * Medical conditions that contraindicate exercise. * Participation in exercise programs (\>2 days/week with training at intensities of 10-15 1RM) in the previous six months. * History of stroke, brain surgery, major depression, or self-reported cognitive impairment that could affect performance in the study. * Cardiovascular, thrombotic, or vascular risk factors (uncontrolled hypertension, peripheral arterial disease, history of deep vein thrombosis or pulmonary embolism, heart failure, severe varicose veins, or uncontrolled anticoagulant therapy). * Skin or local alterations at the cuff application site (ulcers, open wounds, infections, lymphedema, or severe edema). * Inability to communicate normally or with impaired communication skills.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07300384 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 85 Years, studying Severe Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07300384 currently recruiting?
Yes, NCT07300384 is actively recruiting participants. Contact the research team at adrian.escriche@uv.es for enrollment information.
Where is the NCT07300384 trial being conducted?
This trial is being conducted at Valencia, Spain, Valencia, Spain.
Who is sponsoring the NCT07300384 clinical trial?
NCT07300384 is sponsored by University of Valencia. The trial plans to enroll 45 participants.