NCT06399757 A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors
| NCT ID | NCT06399757 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Apollo Therapeutics Ltd |
| Condition | Colorectal Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-06-18 |
| Primary Completion | 2027-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 100 participants in total. It began in 2024-06-18 with a primary completion date of 2027-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is an open-label, Phase 1/2 study to determine the safety, tolerability, and efficacy of APL-5125 for the treatment of selected locally advanced or metastatic solid tumors with particular focus on Colorectal carcinoma (CRC).
Eligibility Criteria
Inclusion Criteria: * 18 years or older * Phase 1: Histologically confirmed locally advanced, inoperable, or metastatic tumor; Colorectal carcinoma, Cholangiocarcinoma, Appendiceal adenocarcinoma. * For Phase 1 sub-studies: Colorectal carcinoma, Cholangiocarcinoma, Appendiceal adenocarcinoma, Pancreatic Adenocarcinoma, Gastric Adenocarcinoma, Endometrial Adenocarcinoma, Triple Negative Breast Cancer, Ovarian Cancer, Prostate Cancer * Phase 2: Colorectal carcinoma * No available standard of care therapy or participant is ineligible for standard of care therapy, except in CRC tumor type in which participant must have previously received all the following therapeutic agents: * fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy * an anti-VEGF therapy * if wt-RAS (wt-KRAS and wt-NRAS), an anti-EGFR therapy * Eastern Cooperative Oncology Group (ECOG) ≤1 * Body Weight ≥40 kg. * Female participants of childbearing potential must have negative serum pregnancy test at screening; must not plan to become pregnant or have ova harvested or breastfeed while on study; must be willing to use specific contraception or avoid intercourse * Male participants must be willing to use specific contraception and not plan to impregnate a female partner or donate sperm while on study * Participant must be willing and able to provide written informed consent and to comply with the requirements of the trial Exclusion Criteria: * Certain medical conditions such as: active brain metastases, carcinomatous meningitis, unstable angina pectoris, myocardial infarction or clinically significant ventricular arrhythmias, symptomatic congestive heart failure, uncontrolled active infection, history of significant hemorrhage within 4 weeks of the first dose date, intestinal disease or major gastric surgery, arterial thrombosis within 6 months of screening * Certain prior therapies such as: anti-cancer treatment within 2 weeks of Cycle 1 Day 1, prior radiotherapy within 14 days before screening, active anti-coagulation therapy, over the counter or prescription medications within 14 days or 5 half-lives prior to cycle 1 day 1, herbal medicines and supplements within 14 days * Major surgery within 1 month of screening * Hemoglobin \< 9.0 g/dL * Absolute neutrophil count \< 1.5 x 10\^9/L * Platelet count \< 100 x 10\^9/L * Hepatic function: 1. Aspartate aminotransferase and/or alanine aminotransferase (ALT) \>3 × upper limit of normal (ULN) (\>5 x ULN for subjects with liver metastases) 2. Total bilirubin \>1.5 × ULN (except participants with Gilbert's syndrome). 3. Albumin \< 3 g/dL * Calculated or measured creatinine clearance of \<60 mL/minute calculated using the formula of Cockcroft and Gault (\[140 - Age\] × Mass \[kg\] / \[72 × serum creatinine mg/dL\]). Multiply result by 0.85 if female. * Fridericia's corrected QT interval (QTcF) \>470 msec or a family history of Long QT Syndrome. * Cardiac function: Echocardiogram (or MUGA) showing Left Ventricular Ejection Fraction (LVEF) \<45% at rest * Infectious diseases: positive for HIV (unless controlled with active retroviral therapy), hepatitis B and hepatitis C
Contact & Investigator
Sanjay Aggarwal, MD
STUDY CHAIR
Apollo Therapeutics Ltd
Frequently Asked Questions
Who can join the NCT06399757 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Colorectal Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06399757 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06399757 currently recruiting?
Yes, NCT06399757 is actively recruiting participants. Contact the research team at AP10@apollotx.com for enrollment information.
Where is the NCT06399757 trial being conducted?
This trial is being conducted at Duarte, United States, Irvine, United States, Sarasota, United States, Ann Arbor, United States and 5 additional locations.
Who is sponsoring the NCT06399757 clinical trial?
NCT06399757 is sponsored by Apollo Therapeutics Ltd. The principal investigator is Sanjay Aggarwal, MD at Apollo Therapeutics Ltd. The trial plans to enroll 100 participants.
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