NCT06955143 A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome
| NCT ID | NCT06955143 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Second Affiliated Hospital of Wenzhou Medical University |
| Condition | Acute Coronary Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 310 participants |
| Start Date | 2025-03-11 |
| Primary Completion | 2025-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 310 participants in total. It began in 2025-03-11 with a primary completion date of 2025-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc. in the blood of patients with ACS (acute coronary syndrome), as well as their correlations with the disease prognosis, based on multi-omics or other related research methods. The main questions it aims to answer are: The growth factors that have significant changes in the peripheral blood of the ACS population, especially fibroblast growth factors? Inflammatory factors and chemokines related to the onset of ACS? The metabolites and proteins that are significantly altered in the peripheral blood after the onset of ACS? Researchers will compare ACS population to CCS (Chronic Coronary Syndrome) population, and control group (patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy).The peripheral venous blood from the participants will be collected within 24 hours after their admission to the hospital.
Eligibility Criteria
Inclusion Criteria: For ACS group STEMI * cTn\>99th ULN or CK-MB\>99th ULN * ST-segment elevation with a convex upward morphology * in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings. NSTEMI * cTn\>99th ULN or CK-MB\>99th ULN * accompanied by one or more of the following situations: persistent ischemic chest pain; new ST-segment depression or low and inverted T waves; echocardiography showing segmental ventricular wall motion abnormalities; abnormal coronary angiography. UA * cTn normal * ischemic chest pain with an electrocardiogram showing transient ST-segment depression or flattened and inverted T waves * evidence of coronary artery stenosis (e.g., CTA demonstrating ≥ 50% stenosis) For CCS group * Clinical Diagnosis Consistent with CCS Categories, meet any one of the following clinical scenarios: Stable Angina Pectoris, Ischemic Cardiomyopathy, Post-ACS Stable Phase, Long-Term CAD Management, Vasospastic or Microvascular Disease, Asymptomatic CAD * Laboratory and Imaging Confirmation: Resting ECG without ST-segment elevation or dynamic changes (excluding ACS), cTn normal or stable (no acute myocardial injury), ≥50% luminal stenosis in ≥1 epicardial coronary artery For control group * Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy Exclusion Criteria: * Lactating or pregnant women * Patients with malignant neoplasms * Severe hepatic/renal dysfunction * Severe hematological disorders * Autoimmune diseases
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06955143 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Acute Coronary Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06955143 currently recruiting?
Yes, NCT06955143 is actively recruiting participants. Contact the research team at davidduoduo@163.com for enrollment information.
Where is the NCT06955143 trial being conducted?
This trial is being conducted at Lishui, China.
Who is sponsoring the NCT06955143 clinical trial?
NCT06955143 is sponsored by Second Affiliated Hospital of Wenzhou Medical University. The trial plans to enroll 310 participants.