NCT03472157 A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients
| NCT ID | NCT03472157 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Lille |
| Condition | Surgery |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2018-06-20 |
| Primary Completion | 2028-06-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2018-06-20 with a primary completion date of 2028-06-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of the study is to demonstrate the superiority of bariatric surgery on the disappearance of NASH without worsening of fibrosis in comparison to medical standard treatment in obese patients (35 kg/m² \> BMI ≥ 30 kg/m²) with NASH complicated of advanced fibrosis (F3 and F4 fibrosis grade according to Brunt score).
Eligibility Criteria
Inclusion Criteria: * Provide written informed consent and agree to comply to the study protocol prior to enrolment. * BMI and Brunt Fibriosis score: * For F3 fibrosis patients: 35\>BMI≥ 30kg/m² ; Fibroscan ≥ 9kPa or FibrometreVM ≥0.526 predicting a F3 fibrosis score grade within 1 month before inclusion or F3 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion. * For F4 fibrosis patients: 50\>BMI≥ 30kg/m² ; Fibroscan ≥ 15kPa predicting a F4 fibrosis score grade within 1 month before inclusion or F4 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion. * Fibroscan ≥ 9kPa or FibrometreVM ≥0.526 predicting a F3 or F4 fibrosis score grade within 1 month before inclusion Or F3 or F4 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion. * Patient should agree to have one liver biopsy during the screening period (before randomization, the randomization will be permitted after at least a second reading performed by pathologist of CHRU Lille to confirm the histological diagnosis of NASH with advanced fibrosis (F3-F4)) for the diagnosis purpose (if no histological biopsy within 1 month before inclusion is available) and one at the end of the treatment period for assessment of the treatment effects. * For patients with cirrhosis, patients must fulfil all the following criteria: Platelets \> 125 000, PT \> 80 %, Albumin \> 35 g/L, MELD score at inclusion \< 9, CPT score \< 6, No history of previous decompensation, No oesophageal varices (endoscopy), No vascular shunt, ASA score ≤ III, Alcohol consumption lower than 20g/day for women and 30g/day for men. * For hypertensive patients, hypertension must be controlled by stable dose of anti-hypertensive medication for at least 2 months prior to screening (and the stable dose can be maintained throughout the study). * Female participating in the study must be either of non-child bearing (surgically sterilized at 6 month prior to screening or postmenopausal) or using an efficient contraception: hormonal contraception (including patch, contraceptive ring etc) intra-uterine device or other mechanical contraception * Patient agrees to come to the study visits within the protocol-specified delay Exclusion Criteria: * Previous history of bariatric surgery (except gastric ring removed for more than 3 years). * Decompensated cirrhosis (MELD\> 7 CPT score\> 5, previous history of decompensation (encephalopathy, ascites, jaundice, varicose vein rupture) * Hepatocellular carcinoma * Platelets \<125 000; TP \<80%; bilirubin \<20 mmol / l; albumin \<35 g / L. * Other liver disease: alcohol consumption exceeding 20 g / day for women and 30g / day in men, HBV, HCV, CBP, CSP, autoimmune hepatitis, hemochromatosis, Wilson's disease, alpha-1 antitrypsin. * Being processed Cancer (chemotherapy, radiotherapy or hormone therapy) * HIV positive patients * Patients who had an acute cardiovascular episode, coronary Heart Disease (Angina pectoris, myocardial infarction, revascularization procedure), stroke or TIA (Transient Ischemic Attack) within the 6 months prior to screening Recent cardiovascular events (stroke, myocardial infarcts, etc…) in the past 6 months. * Severe chronic respiratory disease. * Severe chronic cardiac insufficiency (grade III and IV of NYHA classification). * Pregnant or breastfeeding women. * Simultaneous enrollment in another clinical trial. * Drug abuse within the past year. * Patient with contra-indication for bariatric surgery * Gastic Banding, Biliopancreatic diversion and all the new bariatric surgery techniques are forbidden because the study design allow only the laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric Bypaass. * History of cancer, except: * Patients considered in remission for at least 5 years after onset of treatment. * Patients Treated and believed to be cured basal or squamous cell carcinoma of the skin or resected carcinoma of the cervix
Contact & Investigator
Philippe Mathurin, MD,PhD
PRINCIPAL INVESTIGATOR
University Hospital, Lille
Frequently Asked Questions
Who can join the NCT03472157 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Surgery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03472157 currently recruiting?
Yes, NCT03472157 is actively recruiting participants. Contact the research team at philippe.mathurin@chru-lille.fr for enrollment information.
Where is the NCT03472157 trial being conducted?
This trial is being conducted at Lille, France.
Who is sponsoring the NCT03472157 clinical trial?
NCT03472157 is sponsored by University Hospital, Lille. The principal investigator is Philippe Mathurin, MD,PhD at University Hospital, Lille. The trial plans to enroll 100 participants.