NCT06395402 177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry
| NCT ID | NCT06395402 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | University of Iowa |
| Condition | Neuroendocrine Tumors |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2024-05-03 |
| Primary Completion | 2029-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 120 participants in total. It began in 2024-05-03 with a primary completion date of 2029-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this study is to learn if individualized dosimetry-based prescribing of Lutetium-177 DOTATATE (Lutathera, Novartis Pharmaceuticals) improves treatment outcomes for adults with unresectable neuroendocrine tumors. To investigate this, study participants will: * Undergo Somatostatin Receptor (SSTR) positron emission tomography (PET) imaging, such as a DOTATOC PET/CT scan * Be randomized to receive standard treatment (as per FDA guidelines) or investigational treatment (customized dosing of Lutathera based upon dosimetry) * Undergo blood tests for 4 to 8 weeks after each Lutathera treatment * Complete patient reported outcome questionnaires * Visit the clinic for follow-up about every 8 weeks.
Eligibility Criteria
In order to be eligible to participate in this study, an individual must meet all of the following criteria. A physical, with vital signs, concomitant medication review, and medical history must be completed within 60 calendar days to confirm appropriateness of Lutathera treatment as well as to foundation for listed criteria. Inclusion Criteria: * Provision of signed and dated informed consent form. * Stated willingness to comply with all study procedures and availability for the duration of the study. * Aged ≥ 18 years at time of consent. * Pathologically confirmed (histology or cytology) malignant neoplasm that is determined to be a well-differentiated neuroendocrine tumor (Ki-67 ≤ 20%) with the primary tumor location known or believed to be gastroenteropancreatic origin (GEP-NET) * Disease measuring ≥ 1.5 cm in diameter on CT or MRI as measured per RECIST that shows uptake \> liver background on sstr2 PET/CT with any FDA approved sstr2 imaging agent. SSTR2 PET/CT must have been obtained within 90 days prior to scheduled C1D1 of Lutathera. * Recommended to receive LUTATHERA® therapy for unresectable and/or metastatic neuroendocrine disease. * Adequate performance status (ECOG of 0 or 1; or Karnofsky performance status of ≥70). * Agrees to contraception during therapy. * Neutrophil count within normal limits within 28 days of treatment day 1. * Platelet count within normal limits within 28 days of treatment day 1. * Ability to take oral medication and be willing to adhere to the treatment regimen * For individuals of reproductive potential: agreement to use effective birth control * Agreement to adhere to Lifestyle Considerations throughout study duration: abstain from caffeine or xanthine-containing products as well as alcohol before the start of cycle dosing and through the cycle's final blood sample; minimize social interactions during low blood counts. Exclusion Criteria: * Individuals who are pregnant or lactating (note: potential participants should not engage in 'pump \& dump' strategy; lactation must be discontinued). * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection (requiring inpatient admission or a delay to start of therapy), fever, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Surgery, radiation therapy, or chemotherapy ≤ 4 weeks of C1D1 (Toxicities from prior therapies should have resolved to ≤ CTCAE grade 1 or a new baseline established). * Prior peptide-receptor radiotherapy (PRRT). * Therapeutic investigational drug within 4 weeks of C1D1 (imaging agents are acceptable). * A concurrent malignancy that, in the opinion of the investigator, would cause a safety risk by delaying therapy or confound/negatively impact study objectives (documentation of the rationale must be provided) * Prior external beam radiation dose to the kidneys of \>10 Gy (mean dose to functional renal volume). * Prior external beam radiation (including brachytherapy) involving 25% of the bone marrow (excluding scatter doses of ≤ 5 Gy) as estimated by a radiation oncologist. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to Octreoscan® or Netspot™.
Contact & Investigator
Stephen Graves, Ph.D., DABR
PRINCIPAL INVESTIGATOR
University of Iowa
Frequently Asked Questions
Who can join the NCT06395402 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Neuroendocrine Tumors. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06395402 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06395402 currently recruiting?
Yes, NCT06395402 is actively recruiting participants. Contact the research team at stephen-a-graves@uiowa.edu for enrollment information.
Where is the NCT06395402 trial being conducted?
This trial is being conducted at Iowa City, United States.
Who is sponsoring the NCT06395402 clinical trial?
NCT06395402 is sponsored by University of Iowa. The principal investigator is Stephen Graves, Ph.D., DABR at University of Iowa. The trial plans to enroll 120 participants.