Browse by Phase
Phase 1 / Phase 2 Clinical Trials
Phase 1/2 combined trials evaluate both safety (Phase 1) and preliminary efficacy (Phase 2) in a single study protocol, often used to accelerate early development.
Total Trials
361
Recruiting Now
361
Top Conditions in Phase 1 / Phase 2
NCT06298084 Phase 1, Phase 2
Recruiting
Dose-Expansion Modular Study To Explore the Safety, Tolerability, and Anti-tumor...
Condition
Breast Cancer Metastatic
Enrollment
152 pts
Location
France
Sponsor
Gustave Roussy, Cancer Campus,
NCT07214298 Phase 1, Phase 2
Recruiting
Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metas...
Condition
Metastatic Pancreatic Ductal Adenocarcinoma
Enrollment
35 pts
Location
United States
Sponsor
Roswell Park Cancer Institute
NCT05774899 Phase 1, Phase 2
Recruiting
CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC
Condition
Adenoid Cystic Carcinoma
Enrollment
32 pts
Location
United States
Sponsor
Glenn J. Hanna
NCT06688799 Phase 1, Phase 2
Recruiting
Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Autoimmune Diseases
Condition
Autoimmune Diseases
Enrollment
18 pts
Location
China
Sponsor
Beijing GoBroad Hospital
NCT05455034 Phase 1, Phase 2
Recruiting
Single-cell Sequencing of BLF to Guide the Treatment of Radiation Pneumonitis or...
Condition
Pneumonitis
Enrollment
40 pts
Location
China
Sponsor
Xinqiao Hospital of Chongqing
NCT06895499 Phase 1, Phase 2
Recruiting
Efficacy, Safety, and Tolerability of HB0043 in Hidradenitis Suppurativa Patient...
Condition
Hidradenitis Suppurativa
Enrollment
15 pts
Location
China
Sponsor
Shanghai Huaota Biopharmaceuti
NCT06541509 Phase 1, Phase 2
Recruiting
Mechanisms of Semaglutide Therapy in Heart Failure Patients
Condition
Heart Failure
Enrollment
10 pts
Location
United States, Slovenia
Sponsor
University Medical Centre Ljub
NCT06617793 Phase 1, Phase 2
Recruiting
An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB...
Condition
Relapsing Multiple Sclerosis
Enrollment
28 pts
Location
Australia, France, Germany
Sponsor
Novartis Pharmaceuticals
NCT05006716 Phase 1, Phase 2
Recruiting
A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell M...
Condition
B-cell Malignancy
Enrollment
614 pts
Location
United States, Australia, Brazil
Sponsor
BeOne Medicines
NCT06137144 Phase 1, Phase 2
Recruiting
AZD3470 as Monotherapy and in Combination With Anticancer Agents in Participants...
Condition
Lymphoma
Enrollment
110 pts
Location
United States, Australia, France
Sponsor
AstraZeneca
NCT06681922 Phase 1, Phase 2
Recruiting
A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, an...
Condition
Graft Vs Host Disease
Enrollment
10 pts
Location
United States
Sponsor
Northwell Health
NCT06064812 Phase 1, Phase 2
Recruiting
A Phase I/II Study of FWD1802 in Patients With ER+/HER2- Advanced BC.
Condition
Metastatic Breast Cancer
Enrollment
99 pts
Location
China
Sponsor
Forward Pharmaceuticals Co., L
NCT03523975 Phase 1, Phase 2
Recruiting
Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Man...
Condition
Mantle Cell Lymphoma
Enrollment
28 pts
Location
United States
Sponsor
City of Hope Medical Center
NCT06194929 Phase 1, Phase 2
Recruiting
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of P...
Condition
Cutaneous Melanoma
Enrollment
33 pts
Location
United States
Sponsor
University of Utah
NCT06106672 Phase 1, Phase 2
Recruiting
Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in S...
Condition
Myasthenia Gravis
Enrollment
54 pts
Location
United States
Sponsor
COUR Pharmaceutical Developmen
NCT05560477 Phase 1, Phase 2
Recruiting
Study to Evaluate the Safety and Efficacy of AM3101 to Augment Meniscal Healing
Condition
Meniscus Tear
Enrollment
74 pts
Location
United States
Sponsor
University of Cincinnati
NCT06919666 Phase 1, Phase 2
Recruiting
NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic He...
Condition
Head and Neck Cancer
Enrollment
29 pts
Location
United States
Sponsor
University of Colorado, Denver
NCT07281924 Phase 1, Phase 2
Recruiting
Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
Condition
Metastatic Melanoma
Enrollment
15 pts
Location
United States
Sponsor
University of Wisconsin, Madis
NCT06718686 Phase 1, Phase 2
Recruiting
Rifaximin SSD in Dementia Trial
Condition
Dementia Alzheimer Type
Enrollment
20 pts
Location
United States
Sponsor
Jasmohan Bajaj
NCT06704269 Phase 1, Phase 2
Recruiting
Study to Assess Safety, Efficacy, and Cellular Kinetics of YTB323 in Generalized...
Condition
Generalized Myasthenia Gravis
Enrollment
15 pts
Location
United States, France, Japan
Sponsor
Novartis Pharmaceuticals
NCT04083183 Phase 1, Phase 2
Recruiting
Total Body Irradiation and Astatine-211-Labeled BC8-B10 Monoclonal Antibody for ...
Condition
Non-Malignant Neoplasm
Enrollment
40 pts
Location
United States
Sponsor
Fred Hutchinson Cancer Center
NCT01799538 Phase 1, Phase 2
Recruiting
Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis
Condition
Lymphangioleiomyomatosis
Enrollment
100 pts
Location
United States
Sponsor
National Heart, Lung, and Bloo
NCT06344390 Phase 1, Phase 2
Recruiting
Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke
Condition
Cognitive Impairment
Enrollment
200 pts
Location
China
Sponsor
The First Hospital of Hebei Me
NCT03471260 Phase 1, Phase 2
Recruiting
Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With ...
Condition
Acute Myeloid Leukemia
Enrollment
96 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
NCT07192120 Phase 1, Phase 2
Recruiting
A Study of MHB048C in Patients With Advanced Solid Tumors
Condition
mCRPC (Metastatic Castration-resistant Prostate Cancer)
Enrollment
200 pts
Location
China
Sponsor
Minghui Pharmaceutical (Hangzh
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