🇺🇸 United States Country × Condition
colorectal cancer Clinical Trials in United States
Active clinical trials for colorectal cancer with research sites in United States. All data sourced live from ClinicalTrials.gov — updated daily.
Active Trials: 27 // Recruiting: 27 Phases: Phase 1, Phase 1, Phase 2 // Updated: Daily
Total Trials
27
Recruiting Now
27
Country
🇺🇸 United States
Active Trials in United States (27)
NCT07066657 Phase 1
Recruiting
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Enrollment
572 pts
Country
🇺🇸 United States
ArriVent BioPharma, Inc.
View Trial → NCT05391126
Recruiting
GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care
Enrollment
178 pts
Country
🇺🇸 United States
Reema A. Patel
View Trial → NCT03551951
Recruiting
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Enrollment
320 pts
Country
🇺🇸 United States
University of Missouri-Columbia
View Trial → NCT06324357 Phase 1, Phase 2
Recruiting
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Enrollment
768 pts
Country
🇺🇸 United States
Boehringer Ingelheim
View Trial → NCT04489238
Recruiting
Collection of Information to Better Understand Young Onset Colorectal Cancer
Enrollment
1,366 pts
Country
🇺🇸 United States
Memorial Sloan Kettering Cancer Cen...
View Trial → NCT07033026 Phase 2
Recruiting
An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.
Enrollment
136 pts
Country
🇺🇸 United States
NGM Biopharmaceuticals, Inc
View Trial → NCT07553572
Recruiting
Remote Monitoring and Symptom Management Digital Application
Enrollment
60 pts
Country
🇺🇸 United States
Patrick C. Johnson, MD
View Trial → NCT07436637
Recruiting
Guardant Shield Colorectal Cancer Screening
Enrollment
500 pts
Country
🇺🇸 United States
University of Miami
View Trial → NCT05286814 Phase 2
Recruiting
PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
Enrollment
70 pts
Country
🇺🇸 United States
National Cancer Institute (NCI)
View Trial → NCT06896162
Recruiting
PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival
Enrollment
500 pts
Country
🇺🇸 United States
UNC Lineberger Comprehensive Cancer...
View Trial → NCT06242470 Phase 1
Recruiting
A Study of MGC026 in Participants With Advanced Solid Tumors
Enrollment
250 pts
Country
🇺🇸 United States
MacroGenics
View Trial → NCT04510129
Recruiting
A Multicenter Cancer Biospecimen Collection Study
Enrollment
1,650 pts
Country
🇺🇸 United States
Cofactor Genomics, Inc.
View Trial → NCT05694559
Recruiting
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
Enrollment
1,000 pts
Country
🇺🇸 United States
M.D. Anderson Cancer Center
View Trial → NCT07276529
Recruiting
Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses
Enrollment
30 pts
Country
🇺🇸 United States
GI Windows, Inc.
View Trial → NCT06542835
Recruiting
Community Partnership for Telehealth Solutions to Convey Information and Enhance Care
Enrollment
6,000 pts
Country
🇺🇸 United States
University of Arizona
View Trial → NCT04847063 Phase 1
Recruiting
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Enrollment
60 pts
Country
🇺🇸 United States
National Cancer Institute (NCI)
View Trial → NCT06580002 Phase 2
Recruiting
Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
Enrollment
75 pts
Country
🇺🇸 United States
University of California, Irvine
View Trial → NCT07337590
Recruiting
Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar
Enrollment
80 pts
Country
🇺🇸 United States
Exero Medical Ltd.
View Trial → NCT02838836
Recruiting
Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers
Enrollment
620 pts
Country
🇺🇸 United States
University of Missouri-Columbia
View Trial → NCT06910657 Phase 1
Recruiting
IDOV-Immune for Advanced Solid Tumors
Enrollment
78 pts
Country
🇺🇸 United States
ViroMissile, Inc.
View Trial → NCT07169734 Phase 1, Phase 2
Recruiting
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Enrollment
180 pts
Country
🇺🇸 United States
Alentis Therapeutics AG
View Trial → NCT06598007 Phase 1, Phase 2
Recruiting
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors
Enrollment
78 pts
Country
🇺🇸 United States
Crossignal Therapeutics, Inc.
View Trial → NCT03998202
Recruiting
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
Enrollment
300 pts
Country
🇺🇸 United States
Wake Forest University Health Scien...
View Trial → NCT07216105 Phase 1
Recruiting
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Enrollment
119 pts
Country
🇺🇸 United States
Fate Therapeutics
View Trial → NCT04722341
Recruiting
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
Enrollment
175 pts
Country
🇺🇸 United States
Cedars-Sinai Medical Center
View Trial → NCT06695845 Phase 2
Recruiting
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Enrollment
200 pts
Country
🇺🇸 United States
Jazz Pharmaceuticals
View Trial → NCT04429542 Phase 1
Recruiting
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Enrollment
292 pts
Country
🇺🇸 United States
Bicara Therapeutics
View Trial → Frequently Asked Questions
How many colorectal cancer clinical trials are active in United States?
There are currently 27 active clinical trials for colorectal cancer with sites in United States, of which 27 are actively recruiting patients.
How can I join a colorectal cancer clinical trial in United States?
To join a colorectal cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.
What phases are colorectal cancer trials in United States?
Active colorectal cancer trials in United States span Phase 1, Phase 1, Phase 2, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology