To join a colorectal cancer clinical trial in United States, select a recruiting trial below and check the eligibility criteria. Contact the trial's principal investigator or the listed site in United States directly. All trials listed here are sourced from ClinicalTrials.gov, the official U.S. registry of clinical studies.

What phases are colorectal cancer trials in United States?

Active colorectal cancer trials in United States span Phase 1, Phase 2, Phase 1, Phase 2. Phase I trials test safety, Phase II test efficacy, and Phase III compare against standard treatments in larger patient populations.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology

Active Trials in United States (26)

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

The Florida ASCENT Study

A Study of a Urine Test to Detect Colorectal Cancer

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses

Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Telehealth Intervention for Ostomy Self-Management

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)

Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation

Preserving Fertility After Colorectal Cancer Study

Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

FOG-001 in Locally Advanced or Metastatic Solid Tumors

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

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