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relapsed refractory acute myeloid leukemia
Trial Phases
Phase 2, EARLY_Phase 1, Phase 1
Leukemia clinical trials cover acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL) — distinct diseases with profoundly different biology and treatment approaches. AML research focuses on targeted agents for FLT3, IDH1/2, and TP53-mutated disease, while CLL trials explore fixed-duration venetoclax combinations that achieve treatment-free remissions.
Active trials investigate menin inhibitors for NPM1/KMT2A AML, magrolimab (anti-CD47) combinations, bispecific antibodies in relapsed ALL, and next-generation BTK inhibitors (pirtobrutinib) for ibrutinib-resistant CLL. MRD (minimal residual disease) negativity is emerging as a regulatory endpoint to accelerate approvals.
Top Sponsors
Chinese PLA General Hospital 1 trial
Base Therapeutics (Shanghai) Co., Ltd. 1 trial
Second Affiliated Hospital, School of Medicine, Zhejiang University 1 trial
Recruiting Clinical Trials
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Last Reviewed: April 2026 ·
Data Methodology