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recurrent small lymphocytic lymphoma

Total Trials
2
Recruiting Now
2
Trial Phases
Phase 2, Phase 1

Lymphoma trials span diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, Hodgkin lymphoma, mantle cell lymphoma, and T-cell lymphomas β€” each with distinct biology and treatment response. CAR-T cell therapy has established a new standard in relapsed/refractory DLBCL, and trials now aim to move this approach earlier in the treatment sequence.

Active trials evaluate bispecific antibodies (mosunetuzumab, epcoritamab, glofitamab), next-generation CAR-T cell products (CD19/CD22 dual targets, BCMA-targeting), BTK inhibitors in B-cell lymphomas, and total metabolic volume on PET as a predictive biomarker for treatment adaptation.

Frequently Asked Questions — recurrent small lymphocytic lymphoma Clinical Trials

How many clinical trials are currently recruiting for recurrent small lymphocytic lymphoma?
ClinicalMetric currently tracks 2 actively recruiting clinical trials for recurrent small lymphocytic lymphoma, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 2. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for recurrent small lymphocytic lymphoma?
recurrent small lymphocytic lymphoma research spans Phase 1 (1 trial), Phase 2 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a recurrent small lymphocytic lymphoma clinical trial?
Eligibility criteria for recurrent small lymphocytic lymphoma trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
1
Phase 2
1
Top Sponsors
Fred Hutchinson Cancer Center 1 trial
Mayo Clinic 1 trial

Recruiting Clinical Trials

NCT06839053 Phase 2
Recruiting
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
Enrollment
30 pts
Location
United States
Sponsor
Fred Hutchinson Cancer Center
View Trial →
NCT04892277 Phase 1
Recruiting
CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies
Enrollment
25 pts
Location
United States
Sponsor
Mayo Clinic
View Trial →

Related Conditions

recurrent chronic lymphocytic leukemia (2) refractory chronic lymphocytic leukemia (2) refractory small lymphocytic lymphoma (2) chronic lymphocytic leukemia (1) mantle cell lymphoma (1) recurrent mantle cell lymphoma (1) refractory mantle cell lymphoma (1) small lymphocytic lymphoma (1) recurrent b cell non hodgkin lymphoma (1) recurrent transformed chronic lymphocytic leukemia (1) refractory b cell non hodgkin lymphoma (1) refractory transformed chronic lymphocytic leukemia (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology