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patent foramen ovale

Total Trials
5
Recruiting Now
5
Trial Phases
Phase 3

ClinicalMetric tracks all active clinical trials for patent foramen ovale sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — patent foramen ovale Clinical Trials

How many clinical trials are currently recruiting for patent foramen ovale?
ClinicalMetric currently tracks 5 actively recruiting clinical trials for patent foramen ovale, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 5. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for patent foramen ovale?
patent foramen ovale research spans Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a patent foramen ovale clinical trial?
Eligibility criteria for patent foramen ovale trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3
1
Top Sponsors
Yonsei University 1 trial
Columbia University 1 trial
Josep Rodes-Cabau 1 trial
Recross Cardio, Inc. 1 trial
Peking University Third Hospital 1 trial

Recruiting Clinical Trials

NCT07724171
Recruiting
Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry)
Enrollment
400 pts
Location
South Korea
Sponsor
Yonsei University
View Trial →
NCT07629635 Phase 3
Recruiting
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy
Enrollment
32 pts
Location
United States
Sponsor
Columbia University
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NCT05907694
Recruiting
Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure
Enrollment
714 pts
Location
Canada
Sponsor
Josep Rodes-Cabau
View Trial →
NCT07698951
Recruiting
Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study
Enrollment
15 pts
Location
Serbia
Sponsor
Recross Cardio, Inc.
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NCT06953622
Recruiting
Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale
Enrollment
330 pts
Location
China
Sponsor
Peking University Third Hospit...
View Trial →

Related Conditions

cryptogenic stroke (3) transient ischemic attack due to embolism (1) atrial fibrillation (1) migraine disease (1) older patients (1) medical treatment (1) recurrent stroke (1) pfo (1) pfo patent foramen ovale (1) pfo associated stroke (1) migraine (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology