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myelodysplastic syndromes

Total Trials
19
Recruiting Now
19
Trial Phases
Phase 1, Phase 2, EARLY_Phase 1

ClinicalMetric tracks all active clinical trials for myelodysplastic syndromes sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — myelodysplastic syndromes Clinical Trials

How many clinical trials are currently recruiting for myelodysplastic syndromes?
ClinicalMetric currently tracks 19 actively recruiting clinical trials for myelodysplastic syndromes, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 19. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for myelodysplastic syndromes?
myelodysplastic syndromes research spans Phase 1 (8 trials), Phase 2 (5 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a myelodysplastic syndromes clinical trial?
Eligibility criteria for myelodysplastic syndromes trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
8
Phase 2
5
Phase 3
1
Top Sponsors
Orca Biosystems, Inc. 2 trials
National Cancer Institute (NCI) 2 trials
Stanford University 1 trial
Masonic Cancer Center, University of Minnesota 1 trial
Institute of Hematology & Blood Diseases Hospital, China 1 trial

Recruiting Clinical Trials

NCT06551584 Phase 1
Recruiting
Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT
Enrollment
24 pts
Location
United States
Sponsor
Stanford University
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NCT05805605 Phase 2
Recruiting
Allo HSCT Using RIC and PTCy for Hematological Diseases
Enrollment
56 pts
Location
United States
Sponsor
Masonic Cancer Center, Univers...
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NCT07578675
Recruiting
Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS
Enrollment
323 pts
Location
China
Sponsor
Institute of Hematology & Bloo...
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NCT06146257 Phase 1
Recruiting
A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes
Enrollment
48 pts
Location
United States
Sponsor
GluBio Therapeutics Inc.
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NCT03802695 Phase 1
Recruiting
A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Enrollment
300 pts
Location
United States
Sponsor
Orca Biosystems, Inc.
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NCT07071155 EARLY_Phase 1
Recruiting
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Enrollment
18 pts
Location
United States
Sponsor
Sidney Kimmel Comprehensive Ca...
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NCT06303193 Phase 1, Phase 2
Recruiting
Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
Enrollment
160 pts
Location
United States
Sponsor
National Cancer Institute (NCI...
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NCT07216443 Phase 2
Recruiting
Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
Enrollment
80 pts
Location
United States
Sponsor
Orca Biosystems, Inc.
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NCT05350748
Recruiting
Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS
Enrollment
1,100 pts
Location
United States
Sponsor
National Cancer Institute (NCI...
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NCT05745285
Recruiting
Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care
Enrollment
400 pts
Location
United States
Sponsor
University of Miami
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NCT06297941 Phase 1
Recruiting
Study of REM-422 in Patients With AML or Higher Risk MDS
Enrollment
100 pts
Location
United States, Franc...
Sponsor
Remix Therapeutics
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NCT02720679
Recruiting
Investigation of the Genetics of Hematologic Diseases
Enrollment
1,716 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT04742634 Phase 1, Phase 2
Recruiting
Pre-emptive Therapy With DEC-C to Improve Outcomes in MDS Patients With Measurable Residual Disease Post Allogeneic Hematopoietic Cell Transplant
Enrollment
209 pts
Location
United States
Sponsor
Washington University School o...
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NCT06379945
Recruiting
Unified platforM for a Better integRal Evaluation of MyeLodyspLastic Syndromes in SpAin-Strategy for Unraveling Personalized genoMic Medicine in Public heAlth System (UMBRELLA-SUMMA)
Enrollment
300 pts
Location
Spain
Sponsor
Instituto de Investigación Bio...
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NCT06499285 Phase 3
Recruiting
A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
Enrollment
225 pts
Location
United States, Austr...
Sponsor
Takeda
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NCT04587856
Recruiting
Molecular Mechanisms of Disease Relapse After Allogenic Stem Cell Transplantation in MDS Patients
Enrollment
38 pts
Location
Italy
Sponsor
Gruppo Italiano Malattie EMato...
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NCT06566742 Phase 2
Recruiting
A Phase 2 Study Evaluating Olutasidenib in Patients With IDH1-mutated Clonal Cytopenia of Undetermined Significance and Lower-risk Myelodysplastic/Syndromes/Chronic Myelomonocytic Leukemia.
Enrollment
15 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
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NCT06569095
Recruiting
Predictive Value of Myelodysplastic Syndrome Stem Cells Determined by Multiparameter Flow Cytometry
Enrollment
163 pts
Location
China
Sponsor
Peking University People's Hos...
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NCT07270978 Phase 1
Recruiting
Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS
Enrollment
23 pts
Location
United States
Sponsor
University of Virginia
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Related Conditions

acute myeloid leukemia (5) mixed phenotype acute leukemia (3) myeloproliferative neoplasm (2) chronic myelomonocytic leukemia (2) acute lymphoid leukemia (1) acute myelogenous leukemia (1) acute lymphocytic leukemia (1) biphenotypic acute leukemia (1) undifferentiated leukemia (1) prolymphocytic leukemia (1) chronic myelogenous leukemia (1) plasma cell leukemia (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology