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metastatic castration resistant prostate cancer

Total Trials
11
Recruiting Now
11
Trial Phases
Phase 2, Phase 1, Phase 1, Phase 2

Cancer clinical trials represent the largest single category of recruiting studies worldwide, encompassing everything from early-phase safety studies of novel oncology drugs to large Phase 3 comparisons against current standard-of-care chemotherapy regimens. The field has accelerated dramatically with the rise of immunotherapy, targeted therapies, and CAR-T cell treatments that have transformed outcomes for previously untreatable malignancies.

Trials include checkpoint inhibitors (PD-1/PD-L1 agents), KRAS inhibitors, ADC (antibody-drug conjugates), combination chemotherapy regimens, radiation protocols, and surgical technique comparisons. Many trials stratify by biomarker status (PD-L1 expression, TMB, MSI-H) to identify patients most likely to benefit.

The NCI, pharmaceutical sponsors, and academic cancer centers collectively fund thousands of oncology trials annually across every cancer type.

Frequently Asked Questions — metastatic castration resistant prostate cancer Clinical Trials

How many clinical trials are currently recruiting for metastatic castration resistant prostate cancer?
ClinicalMetric currently tracks 11 actively recruiting clinical trials for metastatic castration resistant prostate cancer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 11. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for metastatic castration resistant prostate cancer?
metastatic castration resistant prostate cancer research spans Phase 1 (4 trials), Phase 2 (4 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a metastatic castration resistant prostate cancer clinical trial?
Eligibility criteria for metastatic castration resistant prostate cancer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
4
Phase 2
4
Top Sponsors
Novartis Pharmaceuticals 2 trials
Peking Union Medical College Hospital 1 trial
AstraZeneca 1 trial
H. Lee Moffitt Cancer Center and Research Institute 1 trial
Peter MacCallum Cancer Centre, Australia 1 trial

Recruiting Clinical Trials

NCT05613738
Recruiting

177Lu-PSMA-EB-01 in Patients With Metastatic Castration-resistant Prostate Cancer

Enrollment
9 pts
Location
China
Sponsor
Peking Union Medical College H...
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NCT06031805
Recruiting

PRostate Olaparib Real World Evidence Study

Enrollment
300 pts
Location
France
Sponsor
AstraZeneca
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NCT07093801
Recruiting

Observational Study on Lutetium (177Lu) Vipivotide Tetraxetan to Treat Metastatic Castration Resistant Prostate Cancer

Enrollment
300 pts
Location
Italy
Sponsor
Novartis Pharmaceuticals
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NCT07476001 Phase 2
Recruiting

Phase 2a Study of High-Dose Testosterone Followed by Radioligand Therapy in mCRPC

Enrollment
12 pts
Location
United States
Sponsor
H. Lee Moffitt Cancer Center a...
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NCT04769817
Recruiting

ProsTIC Registry of Men Treated With PSMA Theranostics

Enrollment
500 pts
Location
Australia
Sponsor
Peter MacCallum Cancer Centre,...
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NCT06029998 Phase 2
Recruiting

Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion

Enrollment
22 pts
Location
United States
Sponsor
University of Utah
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NCT05762536 Phase 2
Recruiting

Docetaxel or Cabazitaxel With or Without Darolutamide in mCRPC

Enrollment
245 pts
Location
Netherlands
Sponsor
Erasmus Medical Center
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NCT06531499 Phase 1
Recruiting

A Study of Radiation Dosimetry, Safety, and Tolerability of Extended Lutetium (177Lu) Vipivotide Tetraxetan Treatment in Chemo-naïve Adults With Metastatic Castration-resistant Prostate Cancer: RADIOpharmaceutical DOSimetry Evaluation (RADIODOSE) Study

Enrollment
106 pts
Location
United States, Germa...
Sponsor
Novartis Pharmaceuticals
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NCT07189403 Phase 1
Recruiting

A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer

Enrollment
40 pts
Location
United States, Franc...
Sponsor
Daiichi Sankyo
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NCT05519449 Phase 1
Recruiting

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

Enrollment
272 pts
Location
United States, Austr...
Sponsor
Janux Therapeutics
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NCT07414940 Phase 1, Phase 2
Recruiting

ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium

Enrollment
60 pts
Location
United Kingdom
Sponsor
University College, London
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology