Epilepsy clinical trials increasingly focus on treatment-resistant epilepsy (TRE) — defined as failure of two adequate antiseizure medication (ASM) trials — where one-third of patients remain uncontrolled. Genetic stratification has driven trials in specific epilepsy syndromes (Dravet, Lennox-Gastaut, SCN1A, KCNQ2) where disease-modifying gene therapy approaches are now being tested.
Active trials investigate fenfluramine for treatment-resistant focal epilepsy, KCNQ2/SCN1A antisense oligonucleotides, sodium selenate for progressive myoclonic epilepsy, novel mTOR inhibitors for TSC-related epilepsy, and responsive neurostimulation (RNS). Seizure frequency and seizure-free rates remain primary endpoints, with ESES and status epilepticus trials gaining traction.
Frequently Asked Questions — epilepsy generalized Clinical Trials
How many clinical trials are currently recruiting for epilepsy generalized?
ClinicalMetric currently tracks 1 actively recruiting clinical trials for epilepsy generalized, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 1. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for epilepsy generalized?
epilepsy generalized research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a epilepsy generalized clinical trial?
Eligibility criteria for epilepsy generalized trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
University of Missouri-Columbia 1 trial
Recruiting Clinical Trials
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional.
Full Disclaimer ·
Last Reviewed: April 2026 ·
Data Methodology