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Medical Condition

down syndrome

Total Trials
10
Recruiting Now
10
Trial Phases
Phase 2

ClinicalMetric tracks all active clinical trials for down syndrome sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — down syndrome Clinical Trials

How many clinical trials are currently recruiting for down syndrome?
ClinicalMetric currently tracks 10 actively recruiting clinical trials for down syndrome, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 10. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for down syndrome?
down syndrome research spans Phase 2 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a down syndrome clinical trial?
Eligibility criteria for down syndrome trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 2
1
Top Sponsors
Riphah International University 5 trials
University of Colorado, Denver 1 trial
Children's Health Ireland 1 trial
Duke University 1 trial
RTI International 1 trial

Recruiting Clinical Trials

NCT01950624
Recruiting
DS-Connect®: The Down Syndrome Registry
Enrollment
100,000 pts
Location
United States
Sponsor
University of Colorado, Denver
View Trial →
NCT06777394
Recruiting
Effects of High Intensity Interval Training in Down Syndrome
Enrollment
30 pts
Location
Pakistan
Sponsor
Riphah International Universit...
View Trial →
NCT06943508
Recruiting
Nordic Walk on Balance and Functional Strength in Children With Down Syndrome
Enrollment
32 pts
Location
Pakistan
Sponsor
Riphah International Universit...
View Trial →
NCT06030349
Recruiting
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
Enrollment
200 pts
Location
Ireland, United King...
Sponsor
Children's Health Ireland
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NCT06955052
Recruiting
The Effects Of "Minds In Motion The Maze" on Balance and Gate In Children With Down Syndrome
Enrollment
20 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT03233646
Recruiting
Retinal Imaging in Neurodegenerative Disease
Enrollment
2,000 pts
Location
United States
Sponsor
Duke University
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NCT06943170
Recruiting
Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome
Enrollment
22 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT07625579
Recruiting
Collaboration for Down Syndrome Progress (CDP)
Enrollment
1,400 pts
Location
United States
Sponsor
RTI International
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NCT06732713
Recruiting
Swiss Ball Versus Frenkel Exercises Effects in Down Syndrome
Enrollment
32 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT06465823 Phase 2
Recruiting
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome
Enrollment
64 pts
Location
Italy
Sponsor
Stefano Vicari
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology