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Medical Condition

down syndrome

Total Trials
9
Recruiting Now
9
Trial Phases
Phase 3

ClinicalMetric tracks all active clinical trials for down syndrome sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — down syndrome Clinical Trials

How many clinical trials are currently recruiting for down syndrome?
ClinicalMetric currently tracks 9 actively recruiting clinical trials for down syndrome, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 9. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for down syndrome?
down syndrome research spans Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a down syndrome clinical trial?
Eligibility criteria for down syndrome trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3
2
Top Sponsors
Institut Jerome Lejeune 1 trial
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 1 trial
University of Central Florida 1 trial
Riphah International University 1 trial
Hôpital le Vinatier 1 trial

Recruiting Clinical Trials

NCT05767216
Recruiting
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome
Enrollment
5 pts
Location
France
Sponsor
Institut Jerome Lejeune
View Trial →
NCT07234695 Phase 3
Recruiting
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
Enrollment
120 pts
Location
Spain
Sponsor
Fundació Institut de Recerca d...
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NCT06512168
Recruiting
Measuring Aided Language Development
Enrollment
60 pts
Location
United States
Sponsor
University of Central Florida
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NCT06977672
Recruiting
Effects of Down Dog Yoga on Pre-writing Skills in Children With Down Syndrome
Enrollment
34 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT06866925
Recruiting
tDCS for Catatonic Depression in Down Syndrome: A Pilot Study
Enrollment
62 pts
Location
France
Sponsor
Hôpital le Vinatier
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NCT06030349
Recruiting
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome
Enrollment
200 pts
Location
Ireland, United King...
Sponsor
Children's Health Ireland
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NCT07044804
Recruiting
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.
Enrollment
36 pts
Location
Italy
Sponsor
Floriana Costanzo
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NCT03233646
Recruiting
Retinal Imaging in Neurodegenerative Disease
Enrollment
2,000 pts
Location
United States
Sponsor
Duke University
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NCT07238465 Phase 3
Recruiting
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Enrollment
200 pts
Location
United States
Sponsor
University of Colorado, Denver
View Trial →

Related Conditions

down syndrome ds (1) down syndrome trisomy 21 (1) alzheimer dementia (1) alzheimer dementia ad (1) alzheimer disease (1) alzheimer disease ad (1) alzheimer blood biomarkers (1) epilepsy (1) seizures (1) cerebral palsy (1) apraxia of speech (1) speech sound disorder (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology