Medical Condition

down syndrome

Total Trials

9

Recruiting Now

9

Trial Phases

Phase 3

ClinicalMetric tracks all active clinical trials for down syndrome sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — down syndrome Clinical Trials

How many clinical trials are currently recruiting for down syndrome?

ClinicalMetric currently tracks 9 actively recruiting clinical trials for down syndrome, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 9. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for down syndrome?

down syndrome research spans Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a down syndrome clinical trial?

Eligibility criteria for down syndrome trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 3

Top Sponsors

Riphah International University 3 trials

Richard Frye 1 trial

Raheel Sanad 1 trial

University of North Carolina, Chapel Hill 1 trial

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 1 trial

Recruiting Clinical Trials

NCT07248449

Recruiting

Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises

Riphah International Universit...

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NCT06213090

Recruiting

Patterns of Neurodevelopmental Disorders

The Effects Of "Minds In Motion The Maze" on Balance and Gate In Children With Down Syndrome

Riphah International Universit...

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NCT07785011

Recruiting

Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome

Physical Activity and Community EmPOWERment Project

University of North Carolina, ...

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NCT07234695 Phase 3

Recruiting

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

Fundació Institut de Recerca d...

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NCT07484464

Recruiting

Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome

Riphah International Universit...

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NCT05767216

Recruiting

Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome

Institut Jerome Lejeune

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NCT06030349

Recruiting

Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome

Enrollment

200 pts

Location

Ireland, United King...

Sponsor

Children's Health Ireland

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Related Conditions

neurodevelopmental disorders (2) autism spectrum disorder (2) epilepsy (2) pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (1) pediatric acute onset neuropsychiatric syndrome (1) mitochondrial encephalomyopathies (1) cerebral folate deficiency (1) intellectual disability (1) fragile x syndrome (1) cri du chat syndrome (1) de lange syndrome (1) mental retardation x linked (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology