NCT05430399 Utidelone Versus Docetaxel in HER2-negative Locally Advanced or Metastatic Breast Cancer
| NCT ID | NCT05430399 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Sun Yat-sen University |
| Condition | Breast Neoplasms |
| Study Type | INTERVENTIONAL |
| Enrollment | 349 participants |
| Start Date | 2022-06-21 |
| Primary Completion | 2025-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 349 participants in total. It began in 2022-06-21 with a primary completion date of 2025-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
It is a phase III trial to explore the efficacy and safety of utidelone versus docetaxel in HER2-negative locally advanced or metastatic breast cancer.
Eligibility Criteria
Inclusion Criteria: * Signed the informed consent form; * Women aged ≥ 18 years; * Patients with locally advanced or metastatic, histologically or cytologically documented breast cancer; * The primary tumor and metastases (if re-biopsy was performed) were both HER2-negative; * Eastern Cooperative Oncology Group (ECOG) score \[0-1\] points; * Patients must have metastatic disease that is evaluable on imaging: including at least one measurable lesion (assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1)); or only non-measurable disease as defined by RECIST 1.1 , especially in patients with bone metastases only, while the disease could be documented/assessed by bone scan, PET or MRI; * Previous chemotherapy with taxane for early breast cancer (eBC; neoadjuvant or adjuvant setting) is permitted if completed ≥12 months before randomization; * No previous chemotherapy for advanced breast cancer ; * For HR+ breast cancer patients shall meet one of the two criteria below: a) radiographically confirmed recurrence or progression within 2 years of adjuvant endocrine therapy; b) received at least one line of endocrine therapy in the recurrence or metastasis stage; * Patients must have recovered to ≤ Grade 1 (CTCAE v5.0) from all toxicities related to prior antineoplastic therapy. However, patients with any grade of alopecia were allowed ; * Patients with asymptomatic CNS metastases may be enrolled, if: 1. Intracranial lesions are evaluable and eligible for systemic therapy only in the absence of extracranial evaluable lesions, or 2. Patients with stable intracranial lesions after local treatment while there are extracranial evaluable lesions ; * Adequate hematological, hepatic and renal function; * Women of childbearing potential must agree to use a contraceptive method during the treatment period and for at least 90 days after the last dose of experiment treatment; * Life expectancy of at least 12 weeks; * Patients must be able to participate and comply with treatment and follow up. Exclusion Criteria: * HER-2 positive (IHC 3+, or FISH positive); * Other malignancies (including primary brain or leptomeninges-related tumors) within the past 5 years, except cured cutaneous basal cell carcinoma and cervical carcinoma in situ; * Patients who have received anti-tumor therapy within 4 weeks prior to the start of study treatment, including chemotherapy, radical radiotherapy, biological therapy, immunotherapy or anti-tumor Chinese medicine therapy; * Patients who have undergone major organ surgery (excluding needle biopsy) or have significant trauma within 4 weeks before the first dose of treatment, or anticipating for a major surgical procedure during the study; * Experienced grade ≥ 3 nervous system-related adverse events after treatment with anti-microtubule drugs; * Symptomatic central nervous system metastases; * Pregnant or lactating women; * Known or suspected hypersensitivity to any of the study drugs or excipients; * Any other non-malignant systemic disease (cardiovascular, renal, hepatic, etc.) that precludes study treatment implementation or follow-up ; * Any other condition that the investigator considers inappropriate to participate in this trial . * Use of corticosteroids is prohibited.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05430399 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Breast Neoplasms. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05430399 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 349 participants.
Is NCT05430399 currently recruiting?
Yes, NCT05430399 is actively recruiting participants. Contact the research team at wangshs@sysucc.org.cn for enrollment information.
Where is the NCT05430399 trial being conducted?
This trial is being conducted at Guangzhou, China, Hunan, China.
Who is sponsoring the NCT05430399 clinical trial?
NCT05430399 is sponsored by Sun Yat-sen University. The trial plans to enroll 349 participants.