NCT06673693 Tislelizumab Combined With SBRT for the Treatment of Head and Neck Squamous Cell Carcinoma
| NCT ID | NCT06673693 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Sun Yat-sen University |
| Condition | Head and Neck Squamous Cell Carcinoma (HNSCC) |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2025-04-15 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 24 participants in total. It began in 2025-04-15 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Exploring the efficacy and safety of Tislelizumab combined with stereotactic body radiation therapy (SBRT) as neoadjuvant treatment for locally advanced head and neck squamous cell carcinoma (HNSCC).
Eligibility Criteria
Inclusion Criteria: * Pathologically confirmed, initially treated, surgically resectable head and neck squamous cell carcinoma. * Clinical stage III to IVB (AJCC 8th edition), except HPV-positive oropharyngeal cancer * Following multidisciplinary discussions involving otolaryngologists and radiation oncologists, the assessment concluded that the tumor is resectable or marginally resectable and suitable for preoperative SBRT * Karnofsky Performance Status score ≥ 70 * Ages 18 to 70 * The primary organ functions meet the test requirements * Patients participate voluntarily and sign informed consent forms Exclusion Criteria: * Patients previously treated with head and neck surgery were excluded from diagnostic biopsies of primary and regional lymph nodes * Previous chemotherapy for any reason, or radiotherapy in the head and neck area, or molecular targeted drug therapy; Previously received anti-PD-1, anti-PD-L1, anti-PD-L2 and other drugs or drugs acting on another irritating or co-inhibitory T cell receptor (such as CTLA-4, OX 40, CD137) treatment, or cell biotherapy * Pregnant or lactating women * Have had or co-had other malignancies * The patient also has a serious, uncontrolled illness * Heart, brain, lung and other important organ function abnormal. Patients with hypertension (systolic blood pressure \>140 mmHg, diastolic blood pressure \>90 mmHg) who cannot be reduced to the normal range by antihypertensive drugs have grade I or above myocardial ischemia or myocardial infarction, arrhythmia, and grade II cardiac insufficiency; Abnormal coagulation function (INR \>1.5 or prothrombin time (PT) \> ULN+4 seconds or APTT \>1.5 ULN), have a tendency to bleed or are receiving thrombolytic or anticoagulant therapy; Have a definite bleeding tendency; Patients with positive urinary protein (urinary protein test 2+ or more, or 24-hour urinary protein quantification \>1.0g) * Glucocorticoid therapy for 30 days prior to initial administration (prednisone equivalent dose \> 10mg daily); Have an active autoimmune disease that has required systemic treatment (i.e., disease-modulating drugs, corticosteroids, or immunosuppressive drugs) in the last 2 years * History of non-infectious pneumonia requiring corticosteroid treatment within 1 year prior to the first dose administration or current presence of interstitial lung disease * Active infections such as tuberculosis that require systemic treatment * A known history of human immunodeficiency virus (HIV) infection (i.e. HIV 1/2 antibody positive) * Untreated active hepatitis B; Note: Hepatitis B subjects who met the following criteria were also eligible for inclusion: HBV viral load must be \<1000 copies /ml (200 IU/ml) prior to initial dosing, and subjects should receive anti-HBV therapy to avoid viral reactivation throughout study chemotherapeutic therapy. Subjects with anti-HBC (+), HBsAg (-), anti-HBS (-) and HBV viral load (-) do not need to receive prophylactic anti-HBV therapy, but need to closely monitor viral reactivation. Active HCV-infected subjects (HCV antibody positive and HCV-RNA levels above the lower limit of detection) * Patients who have a history of psychotropic substance abuse and cannot abstain or have mental disorders * The investigator determines other circumstances that may affect the conduct of the clinical study and the determination of the study results * While participating in another therapeutic clinical study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06673693 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Head and Neck Squamous Cell Carcinoma (HNSCC). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06673693 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06673693 currently recruiting?
Yes, NCT06673693 is actively recruiting participants. Contact the research team at chenchuny@sysucc.org.cn for enrollment information.
Where is the NCT06673693 trial being conducted?
This trial is being conducted at Guangzhou, China, Guangzhou, China.
Who is sponsoring the NCT06673693 clinical trial?
NCT06673693 is sponsored by Sun Yat-sen University. The trial plans to enroll 24 participants.