NCT05574634 The Role of the Locus Coeruleus in Age-related Distractibility
| NCT ID | NCT05574634 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Virginia Polytechnic Institute and State University |
| Condition | Aging |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2023-04-11 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2023-04-11 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
Eligibility Criteria
Inclusion: * Healthy adult participants * No younger than 18 and no older than 75 yrs of age * Ability to provide written informed consent Exclusion: * History of surgery involving metal implants * Possible metal fragments in the eyes * Pacemaker * A history of claustrophobia * Braces * Weighing over 250 pounds * Pregnant or possibility of being pregnant. * Severe medical or psychiatric conditions (e.g., blind or deaf, head trauma) * Learning disabilities or developmental disabilities
Contact & Investigator
Tae-Ho Lee, PhD
PRINCIPAL INVESTIGATOR
Virginia Polytechnic Institute and State University
Frequently Asked Questions
Who can join the NCT05574634 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Aging. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05574634 currently recruiting?
Yes, NCT05574634 is actively recruiting participants. Contact the research team at taehol@vt.edu for enrollment information.
Where is the NCT05574634 trial being conducted?
This trial is being conducted at Blacksburg, United States.
Who is sponsoring the NCT05574634 clinical trial?
NCT05574634 is sponsored by Virginia Polytechnic Institute and State University. The principal investigator is Tae-Ho Lee, PhD at Virginia Polytechnic Institute and State University. The trial plans to enroll 200 participants.