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Recruiting NCT05169333

NCT05169333 The Oxford Risk Factors And Non-Invasive Imaging Study

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Clinical Trial Summary
NCT ID NCT05169333
Status Recruiting
Phase
Sponsor University of Oxford
Condition Cardiovascular Diseases
Study Type OBSERVATIONAL
Enrollment 250,000 participants
Start Date 2016-02-23
Primary Completion 2030-02

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age 99 Years
Study Type OBSERVATIONAL

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 250,000 participants in total. It began in 2016-02-23 with a primary completion date of 2030-02.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Eligibility Criteria

Inclusion Criteria: Inclusion Criteria for study Arms 1, 2 and 3: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 -99 years. Inclusion Criteria for study Arm 4: • Male or Female, aged 18 -99 years. Exclusion Criteria: Exclusion Criteria for Study Arms 1, 2 and 3: * Unable or unwilling to consent * Active cancer Exclusion Criteria for Study Arm 4: * Participation in Study Arms 1, 2 or 3 * Existing opt-out from use of data for research purposes

Contact & Investigator

Central Contact
Principal Investigator

Antoniades

PRINCIPAL INVESTIGATOR

University of Oxford

Frequently Asked Questions

Who can join the NCT05169333 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying Cardiovascular Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05169333 currently recruiting?

Yes, NCT05169333 is actively recruiting participants. Contact the research team at kenneth.chan@cardiov.ox.ac.uk for enrollment information.

Where is the NCT05169333 trial being conducted?

This trial is being conducted at Bethesda, United States, Rochester, United States, Cleveland, United States, Adelaide, Australia and 11 additional locations.

Who is sponsoring the NCT05169333 clinical trial?

NCT05169333 is sponsored by University of Oxford. The principal investigator is Antoniades at University of Oxford. The trial plans to enroll 250,000 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology