NCT06399263 Study of Psilocybin for Anorexia in Young Adults
| NCT ID | NCT06399263 |
| Status | Recruiting |
| Phase | Phase 2 |
| Sponsor | Marissa Raymond-Flesch, MD, MPH |
| Condition | Anorexia Nervosa |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-11-18 |
| Primary Completion | 2029-11 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
In Phase 2, researchers evaluate early signs of effectiveness. You may be randomized to receive the active treatment or a comparator. Monitoring continues closely.
This trial targets 40 participants in total. It began in 2024-11-18 with a primary completion date of 2029-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a single site trial of psilocybin therapy for the treatment of refractory Anorexia Nervosa in young adults. The psilocybin therapy will include three preparatory sessions, psilocybin dosing session one (20mg), two integration sessions, psilocybin dosing session two (up to 25mg), and three final integration sessions. Eating disorder symptoms will be measured pre and post treatment. One to two family member(s) of each young adult participant will be enrolled in the study. One of which will be required to attend a portion of two preparatory sessions and a portion of two integration sessions and receive psychoeducation about supporting the young adult participant through preparation and integration for psilocybin therapy. Investigators hypothesize that psilocybin will increase cognitive flexibility and that this increase will predict long-term changes in cognitive rigidity, habitual eating, and exercise behaviors in patients with Anorexia Nervosa.
Eligibility Criteria
Inclusion Criteria: * Able to understand and provide informed consent. * Between 18 and 25 years old at time of screening. * Meets Diagnostic and Statistical Manual (DSM-5) criteria for any type of Anorexia Nervosa * Currently experiencing symptoms of Anorexia Nervosa * Comfortable reading and writing in English * Have no anticipated changes in medication or surgical procedures for trial duration * Commit to attend all in-person and remote study visits and participate in all data collection procedures * Able to identify one or two family members or close friends to co-enroll in the study, who will be required to participate in select therapy sessions. * Agree to use a highly effective form of contraception for two weeks prior to starting the study and one month after finishing the study. * Agree that for one week preceding each psilocybin session, they will refrain from taking any nonprescription medication, nutritional supplement, or herbal supplement except when approved by the research team. Exceptions will be evaluated by the research team and will include acetaminophen, non-steroidal anti-inflammatory drugs, and common doses of vitamins and minerals. * Agree to consume approximately the same amount of caffeine-containing beverages (e.g., coffee, tea) that they usually consume before arriving at the research unit on the mornings of psilocybin administration sessions. If the young adult participant does not routinely consume caffeinated beverages, they must agree not to do so prior to psilocybin administration sessions. Exclusion Criteria: * Current known pregnancy or positive pregnancy test at any time during the study * Personal history of bipolar disorder, or psychotic disorder verified by the Structured Clinical Interview for DSM-5 (SCID) and medical history at screening * Body Mass Index less than 12 at screening * Unstable vital signs including Blood Pressure, Heart Rate, or Temperature * Abnormal Safety Labs including sodium, potassium, magnesium, phosphorus, creatinine, estimated Glomerular Filtration Rate, Aspartate Transferase, Alanine Transaminase * Electrocardiogram abnormalities * Hospitalization or participation in a residential program for more than 2 of the past 4 weeks at the time of screening. * Unwilling to abstain from alcohol, Cannabidiol (CBD), tetrahydrocannabinol (THC), marijuana, and illicit drug use for 48 hours pre and post psilocybin dosing days and abstain from nicotine for 10 hours pre and post psilocybin dosing. * Positive urine toxicology testing for amphetamines, benzodiazepines, cocaine, cannabis, 3,4-Methylenedioxymethamphetamine (MDMA), and opioids (including methadone and buprenorphine) on the morning of either psilocybin administration session. * History of cardiovascular disease * Uncontrolled endocrine conditions, including diabetes, hyper or hypothyroidism * Significant and uncontrolled gastrointestinal illness at the discretion of the investigator * Significant and uncontrolled neurological disease including uncontrolled seizure disorder at the discretion of the investigator * Use of any prohibited concomitant medications or inability or unwillingness to discontinue according to the study's prescribed medication taper or tapering with the participants primary prescriber. * Needle phobia. * Simultaneous enrollment in another clinical trial. * Pregnant or Breast feeding. * Allergy or intolerance to any of the materials contained in the drug product * History of severe reaction to psychedelics at the discretion of the investigators. * High risk of self-harm/suicide * Mental health condition that will prevent engagement with the treatment team. * Unwilling or unable to participate in the treatment protocol as planned, including hydration with sports drinks on dosing days. * If any study physician feels that it would be unsafe to continue for any mental, physical or other reason
Contact & Investigator
Marissa Raymond-Flesch, MD
PRINCIPAL INVESTIGATOR
University of California, San Francisco
Frequently Asked Questions
Who can join the NCT06399263 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 25 Years, studying Anorexia Nervosa. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06399263 trial and what does that mean for participants?
Phase 2 trials evaluate whether the treatment shows signs of effectiveness while continuing to monitor safety. More participants are enrolled than in Phase 1 to help refine the treatment protocol.
Is NCT06399263 currently recruiting?
Yes, NCT06399263 is actively recruiting participants. Contact the research team at psilocybin.an.study@ucsf.edu for enrollment information.
Where is the NCT06399263 trial being conducted?
This trial is being conducted at San Francisco, United States, San Francisco, United States.
Who is sponsoring the NCT06399263 clinical trial?
NCT06399263 is sponsored by Marissa Raymond-Flesch, MD, MPH. The principal investigator is Marissa Raymond-Flesch, MD at University of California, San Francisco. The trial plans to enroll 40 participants.