NCT04888923 Natural History of the Human Biological Response to Environmental Exposure and Injury
| NCT ID | NCT04888923 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Institute of Environmental Health Sciences (NIEHS) |
| Condition | Inflammation |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,000 participants |
| Start Date | 2021-11-16 |
| Primary Completion | 2031-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,000 participants in total. It began in 2021-11-16 with a primary completion date of 2031-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background: Environmental exposures like pollution, diet, and stress can help cause human diseases, or make them worse. Researchers want to better understand how injury and inflammation are caused by these exposures. They want to collect biological and environmental samples and other data. They may use the samples to measure a range of factors, like hormones, toxins, and chemicals. This will help them improve their studies. Objective: To identify and understand how environmental exposures contribute to human disease. Eligibility: Healthy adults ages 18 and older Design: Participants will be screened with questions about their health history, demographics, and medicines they take. Participants may give blood, hair, stool, saliva, and/or urine samples. They may have a skin punch biopsy to collect skin cells. They may give fingernail or toenail clippings. They may give a sample of exhaled breath. Participants may give a sputum sample. They will inhale a saline mist and cough mucus into a cup. Participants may have their nasal passages brushed, scraped, or washed. Participants may give cheek cell samples. They will swish mouthwash and spit it into a cup. Participants who produce sperm may give samples. Participants may have bronchoscopy to collect fluid. A saline solution will be put into their lung and then suctioned out, washing areas of the lung. Participants may have a pelvic or transvaginal ultrasound. They may have lung function tests. Participants may collect household dust, urine, or stool at home. Participants will complete surveys about their health, diet, and exposures. Participation will last for one or more study visits. Participants may be contacted in the future to take part in other studies.
Eligibility Criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study. 2. Ability to provide informed consent. 3. Able to read and speak English. 4. Male or female, aged greater than or equal to 18. 5. Able to travel to the NIEHS CRU for study visits. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Not willing to have samples stored for future use. 2. Current pregnancy or lactation, by participant verbal confirmation. 3. Any condition that, in the investigator s opinion, places the participant at undue risk for complications associated with required study procedures.
Contact & Investigator
Lawrence S Kirschner, M.D.
PRINCIPAL INVESTIGATOR
National Institute of Environmental Health Sciences (NIEHS)
Frequently Asked Questions
Who can join the NCT04888923 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Inflammation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04888923 currently recruiting?
Yes, NCT04888923 is actively recruiting participants. Contact the research team at myniehs@nih.gov for enrollment information.
Where is the NCT04888923 trial being conducted?
This trial is being conducted at Research Triangle Park, United States.
Who is sponsoring the NCT04888923 clinical trial?
NCT04888923 is sponsored by National Institute of Environmental Health Sciences (NIEHS). The principal investigator is Lawrence S Kirschner, M.D. at National Institute of Environmental Health Sciences (NIEHS). The trial plans to enroll 2,000 participants.