NCT07536516 Measurement of Ocular Blood Flow and Retinal Oxygen Extraction in Diabetic Patients
| NCT ID | NCT07536516 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of Vienna |
| Condition | Diabetes Mellitus |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-11-28 |
| Primary Completion | 2026-05-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2025-11-28 with a primary completion date of 2026-05-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The prevalence of diabetes is increasing, with type 2 diabetes mellitus comprising over 90% of cases. Diabetes mellitus complications, including diabetic retinopathy (DR), impose significant health burdens. GLP-1 receptor agonists (GLP-1RAs) and dual GIP/GLP-1 receptor agonists show promise in improving cardiovascular and kidney outcomes, but their effects on retinal microvasculature and neuroprotection remain unclear. This study investigates the impact of GLP-1RAs (semaglutide, liraglutide) and GIP/GLP-1-dual agonists (tirzepatide) on ocular blood flow and retinal function in DM patients.
Eligibility Criteria
Inclusion Criteria: * Men and women aged ≥ 18 years * Signed informed consent * Previously diagnosed diabetes mellitus * Normal ophthalmic findings except diabetic retinopathy, unless the investigator considers an abnormality to be clinically irrelevant * Planned initiation of therapy with GLP-1 receptor agonist (Semaglutide, Ozempic®; Liraglutide, Victoza®) or GIP/GLP-1 receptor agonist (Tirzepatide, Mounjaro®) by a diabetes specialist Exclusion Criteria: * Participation in a clinical trial in the 3 weeks preceding the screening visit * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Presence or history of a severe medical condition, except diabetes, as judged by the clinical investigator * Abuse of alcoholic beverages * Blood donation during the previous three weeks * Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator * Previous laser photocoagulation treatment in the study eye * Best corrected visual acuity \< 0.4 Snellen * Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception * Pregnancy, planned pregnancy or lactation
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07536516 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Diabetes Mellitus. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07536516 currently recruiting?
Yes, NCT07536516 is actively recruiting participants. Contact the research team at doreen.schmidl@meduniwien.ac.at for enrollment information.
Where is the NCT07536516 trial being conducted?
This trial is being conducted at Vienna, Austria.
Who is sponsoring the NCT07536516 clinical trial?
NCT07536516 is sponsored by Medical University of Vienna. The trial plans to enroll 20 participants.
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