NCT06496282 Lemborexant on Improving Sleep Quality Among Hospital Rotating Shift Workers
| NCT ID | NCT06496282 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Phramongkutklao College of Medicine and Hospital |
| Condition | Sleep |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2024-08 |
| Primary Completion | 2026-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 50 participants in total. It began in 2024-08 with a primary completion date of 2026-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Shift Work Sleep Disorder (SWSD) are caused by working shifts with a wake-up schedule and sleeping in a way that is different from the natural way of sleeping and avoiding sleep usually results in deviations. of the biological clock (Biological clock), which is an important cause of sleep problems including insomnia, excessive sleepiness or daytime sleepiness these problems was associated cadiovascular events, decrease quality of life and long term working. At the present there are limited information regarding the effectiveness of medications used to promote sleep in shift workers. Lemborexant is specific in binding to orexin type 2, which has a direct effect on sleep. and there are limited biomarkers monitoring from the use of lemborexant including still not found. Which studies have followed depressive symptoms, anxiety symptoms and cognition from a group of people with insomnia, the aim of study to assessment effectiveness of lemborexant on sleep efficiency, quality of life, symptoms of depression, cognition, BDNF, CRP, IL-6 and TNF-alpha levels. of volunteers working on rotating shifts.
Eligibility Criteria
Inclusion Criteria: * Age 20-60 years * Rotating shift workers at least 3 months and continue rotating shift until end of study * Participants who have sleep problem especially total sleep time lower than 6 hours and/or unable to sleep effectively according to the ICSD-3 at least 1 criteria * Participants who have sleepy while working and have Epworth sleepiness scale in shift grater than or equal to 10 points Exclusion Criteria: * Receiving drug interaction esp. drugs induced CYP3A4 (moderate to severe) or drugs inhibited CYP3A4 (moderate to severe) * Untreatment mental health disease or in process medication adjustment * Hepatic function in Chid-Pugh C * Pregnancy * Breastfeeding * Participants who in process medication adjustment such as mental heat, neurology, insomnia, contraceptive drugs. * Diagnosis obstructive sleep apnea (OSA) with or without CPAP using or diagnosis restless leg syndrome or circadian rhythm disorders or narcolepsy * Complex sleep behaviors such as sleep driving, sleep phone, sleep cooking * HAM-D grater than or equal to 24 points * HAM-A grater than or equal to 24 points * Caffeine taking grater than 400 mg/day or can't not hold caffeine 4 hours before bedtime * Substance abuse or alcoholism within 2 years ago * Alcohol intake grater than 140 g of alcohol per week in female or intake grater than 210 g of alcohol per week in male or can't control alcohol drinking greater than 20 g of alcohol per day or can't hold alcohol within 3 hours before bedtime * Cannabinoid using within 1 week ago * Participants who have underlying disease such as stroke, atrial fibrillation, chronic obstructive pulmonary disease, hepatic impairment, severe renal impairment, cognitive impairment, cancer, chronic pain * Participant who use of benzodiazepine or non-benzodiazepine in treatment of insomnia * Participant who have nocturia problem * Participant who have mental health problem which the physician conclude it affect the safety of participant * Participant who have suicidal thinking with or without plan or have suicidal behaviors within 10 years ago * Participant who have major surgery schedule during the study * Travel across greater than 3 time zone within 2 weeks before include participant * Allergy of lemborexant or component of lemborexant * Have previously participated in study that used lemborexant * Participant who
Contact & Investigator
Tipvilai Taweepunturat, Pharm.D.
STUDY CHAIR
Faculty of Pharmacy Siam University
Frequently Asked Questions
Who can join the NCT06496282 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 60 Years, studying Sleep. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06496282 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 50 participants.
Is NCT06496282 currently recruiting?
Yes, NCT06496282 is actively recruiting participants. Contact the research team at taribtip@gmail.com for enrollment information.
Where is the NCT06496282 trial being conducted?
This trial is being conducted at Ratchathewi, Thailand.
Who is sponsoring the NCT06496282 clinical trial?
NCT06496282 is sponsored by Phramongkutklao College of Medicine and Hospital. The principal investigator is Tipvilai Taweepunturat, Pharm.D. at Faculty of Pharmacy Siam University. The trial plans to enroll 50 participants.