NCT07435766 Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy
| NCT ID | NCT07435766 |
| Status | Recruiting |
| Phase | — |
| Sponsor | ETH Zurich |
| Condition | Pregnancy |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-03-02 |
| Primary Completion | 2026-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2026-03-02 with a primary completion date of 2026-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.
Eligibility Criteria
Inclusion Criteria: * female * pregnant at gestational age 12 (±1) weeks (dated by ultrasound) * age 18 to 35 y * Hb concentration ≥80 g/L * absence of significant inflammation * body weight \<80 kg * no major chronic diseases * no intake of vitamin and mineral supplements outside of this study in the 1-2 weeks between screening and study start and during the study * no blood transfusion, blood donation, or significant blood loss over the past 4 months Exclusion Criteria: * severe anemia (defined as Hb \<80 g/L) * malaria * sickle cell disease (SS and SC) * hemoglobin C disease (CC).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07435766 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 35 Years, studying Pregnancy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07435766 currently recruiting?
Yes, NCT07435766 is actively recruiting participants. Contact the research team at laura.wasserfallen@pharma.ethz.ch for enrollment information.
Where is the NCT07435766 trial being conducted?
This trial is being conducted at Kwale, Kenya, Msambweni, Kenya.
Who is sponsoring the NCT07435766 clinical trial?
NCT07435766 is sponsored by ETH Zurich. The trial plans to enroll 50 participants.