NCT06579248 Intraoral Hypothermia Device for Preserving Taste During Radiation
| NCT ID | NCT06579248 |
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Sponsor | Henry Ford Health System |
| Condition | Head and Neck Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-11-12 |
| Primary Completion | 2026-08-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 15 participants in total. It began in 2024-11-12 with a primary completion date of 2026-08-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Radiation therapy to the head and neck region is known to cause taste dysfunction. Preliminary studies showed that cooling normal structures may lower damage caused by radiation. The purpose of this research study is to see if it is feasible to use an intraoral cooling device during radiation treatments to preserve or lower the decline of taste function.
Eligibility Criteria
Inclusion Criteria: * Patients being treated with combination radiation therapy and chemotherapy (definitive) for locally advanced (AJCC 8th cT3-4 or cN+) squamous cell carcinoma of the larynx. * Age ≥ 18. * Eastern Cooperative Oncology Group (ECOG) performance status 0-1. * Patients will engage in the informed consent process and provide study-specific informed consent prior to study entry and must be able to fill out toxicity and quality of life related questionnaires. * Patients should be concurrently treated with any of the following chemotherapy drugs: cisplatin, carboplatin, and cetuximab. Exclusion Criteria: * Patients receiving other forms of therapy intended to reduce taste dysfunction. * Patients with metastatic disease. * Patient with allergies or hypersensitivity to materials in the intraoral bolus. * Patients who have received prior chemotherapy or radiation therapy for head and neck cancer. * Patients who decline to use or cannot tolerate the intraoral device. * Patients who are current or recent (within 3 months of treatment initiation) cigarette smokers. * Patients who are unable to complete the required forms; however, verbal completion is adequate if recorded on the form daily. * Patients with uncontrolled serious illness including, but not limited to, ongoing or serious active infection requiring IV antibiotics for over 30 days, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia other than chronic, stable atrial fibrillation, immunocompromised state, significant hepatic insufficiency, significant hematological disease, and any serious or unstable psychological condition. * Patients who are on any of the following medication that cannot find a suitable substitute during the study period: acetazolamide, maribavir (TAK-620, Phase 3 trial drug), eszopiclone, topiramate, captopril, lithium, procainamide, terbinafine, and amiodarone. * Patients who have taste loss at baseline, assessed subjectively and objectively at the first encounter, will be excluded from the study and all analysis. They will be replaced with a new patient. * Patients who have tested positive for COVID-19 during the study period.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06579248 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Head and Neck Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06579248 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06579248 currently recruiting?
Yes, NCT06579248 is actively recruiting participants. Contact the research team at mgilber6@hfhs.org for enrollment information.
Where is the NCT06579248 trial being conducted?
This trial is being conducted at Detroit, United States.
Who is sponsoring the NCT06579248 clinical trial?
NCT06579248 is sponsored by Henry Ford Health System. The trial plans to enroll 15 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.