NCT05438459 GAIA-102 Intraperitoneal Administration in Patients With Advanced Gastrointestinal Cancer of Microsatellite Stable With Malignant Ascites
| NCT ID | NCT05438459 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | Kyushu University |
| Condition | Gastric Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 130 participants |
| Start Date | 2022-06-08 |
| Primary Completion | 2028-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 130 participants in total. It began in 2022-06-08 with a primary completion date of 2028-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Phase I Part : Confirm the safety of GAIA-102 as a monotherapy or GAIA-102 and pembrolizumab in combination for advanced gastrointestinal cancer of microsatellite stable with malignant ascites, and determine the recommended number of doses for Phase II part. Phase II Part : Research the efficacy and safety of as a monotherapy or GAIA-102 and pembrolizumab for advanced gastrointestinal cancer of microsatellite stable with malignant ascites at the recommended dose of GAIA-102 decided in the Phase I part.
Eligibility Criteria
Inclusion Criteria: 1. Unresectable or advanced recurrent gastric cancer with evident peritoneal dissemination on imaging, or with ascites, as well as unresectable or advanced recurrent pancreatic cancer. 2. Phase I: Patients with gastric cancer who have received 3 or more prior chemotherapy regimens and are refractory or intolerant to these therapies, and patients with pancreatic cancer who have received 2 or more prior chemotherapy regimens and are refractory or intolerant to these therapies. Phase II: Patients with gastric cancer who have received 2 or more prior chemotherapy regimens, including at least 1 regimen containing an immune checkpoint inhibitor, and are refractory or intolerant to these therapies, and patients with pancreatic cancer who have received 1 or more prior chemotherapy regimens and are refractory or intolerant to these therapies. 3. Abdominal port placement is possible 4. No medical history of serious side effects or allergic reactions to pembrolizumab (only for patients in the pembrolizumab combination cohort) 5. Diagnosed gastric adenocarcinoma or pancreatic cancer with by histological or cytological examination 6. The patient has been confirmed to be "negative (not MSS = MSI-high)" by microsatellite instability (MSI) testing, or "proficient mismatch repair (pMMR)" by mismatch repair protein immunohistochemistry testing 7. The Eastern Cooperative Oncology Group (ECOG) performance status(PS) at the time of informed consent meets the following conditions. * Phase I ：0-2 * Phase II ：0-1 8. Patient aged 20years or older 9. Adequate major organs (bone marrow, heart, lungs, liver, kidneys, etc.) function: * Neutrophil ≧1,500/mm3 * hemoglobin ≧8.0 g/dL * Platelet ≧75,000/mm3 * PT-INR≦ 1.5 * AST, ALT≦ 3 times the upper limit of reference value * T-Bil≦ 2 times the upper limit of reference value (T-Bil ≦ 3.0mg/dL , when drainage for obstructive jaundice) * eGFR ≧30mL/min/1.73m2 10. Expected to survive for 3 months or more at the enrollment 11. Written informed consent Exclusion Criteria: 1. Untreated cranial metastases. 2. Diagnosed with meningeal carcinomatosis 3. Received allogeneic hematopoietic stem cell transplantation 4. Participated in other clinical trials / clinical trials within 30 days prior to obtaining written consent and used or had used the investigational product or investigational equipment. 5. Existence or suspected active autoimmune disease 6. Continued systemic immunosuppressive therapy with corticosteroids in excess of 10 mg / day in terms of prednisolone or other immunosuppressants within 14 days prior to investigational product administration 7. Symptomatic interstitial pneumonia, or even if it is not symptomatic, it may interfere with diagnostic imaging in detecting new pneumonitis caused by the investigational product used in the clinical trial. 8. Have active double cancer and need treatment for the double cancer 9. Requires treatment as shown in "Unacceptable Combination / Supportive Therapy" during the clinical trial period 10. Have a medical history of severe hypersensitivity to immune checkpoint inhibitors or immune-related adverse events requiring treatment 11. Have one of the following complications * Complication of cerebrovascular disorder with symptoms or history within 6 months before the enrollment * Active gastrointestinal perforation, fistula, diverticulitis * Symptomatic congestive heart failure * Bleeding tendency * Presence of blood clots that may cause embolism on the image * Unhealed fractures (excluding compression fractures associated with osteoporosis) or severe wounds requiring medical treatment * Uncontrollable digestive ulcer * Active infectious diseases requiring intravenous administration of antibiotics, antifungal agents or antiviral agents * HIV antibody positive 12. At the time of the enrollment, the period from the following prior treatment or the end of treatment has not passed. * Surgery (including exploratory laparotomy / examination laparoscope): 2 weeks * Palliative radiotherapy: 1 week * Thoracic drainage: 1 week * Pretreatment antineoplastic (from the last administration): 3 weeks * Biopsy with incision, thoracic biopsy, treatment for trauma (excluding patients without wound healing), etc : 2 weeks 13. Scheduled thoracotomy or abdominal surgery during the clinical trial period 14. It is judged that it is difficult to enroll in this study due to clinically significant mental illness. 15. Pregnant women, lactating women, women who are currently pregnant, or have no intention of contraception for 4 months after consent is obtained. 16. Allergic to antibiotics and foreign animal-derived ingredients (pig and mouse) 17. Difficult to participate in the trial by the investigator
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05438459 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, studying Gastric Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT05438459 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT05438459 currently recruiting?
Yes, NCT05438459 is actively recruiting participants. Contact the research team at oki.eiji.857@m.kyushu-u.ac.jp for enrollment information.
Where is the NCT05438459 trial being conducted?
This trial is being conducted at Fukuoka, Japan.
Who is sponsoring the NCT05438459 clinical trial?
NCT05438459 is sponsored by Kyushu University. The trial plans to enroll 130 participants.
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