NCT06827184 By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
| NCT ID | NCT06827184 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Acute Respiratory Distress Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-09-20 |
| Primary Completion | 2030-08-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2024-09-20 with a primary completion date of 2030-08-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.
Eligibility Criteria
Inclusion Criteria: 1. Acute respiratory distress syndrome 2. Age \> 18 3. Serial arterial blood gas data：PaO2/FiO2 \<150. The mechanical ventilator setting：FiO2\>0.6, PEEP\>5 cmH2O Exclusion Criteria: 1. Implantable electronic devices (e.g., pacemakers) 2. Body mass index \> 30 3. Major thoracic and abdominal surgery 4. Patients with unstable spine and pelvis conditions 5. Pregnant women in the second and third trimesters 6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure 7. Hemodynamically unstable patients unsuitable for prone ventilation therapy 8. Patients with active seizures
Contact & Investigator
Ting-Yu Liao, MD
PRINCIPAL INVESTIGATOR
National Taiwan University Hospital
Frequently Asked Questions
Who can join the NCT06827184 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Acute Respiratory Distress Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06827184 currently recruiting?
Yes, NCT06827184 is actively recruiting participants. Contact the research team at tingyuliao@ntuh.gov.tw for enrollment information.
Where is the NCT06827184 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT06827184 clinical trial?
NCT06827184 is sponsored by National Taiwan University Hospital. The principal investigator is Ting-Yu Liao, MD at National Taiwan University Hospital. The trial plans to enroll 100 participants.