NCT07648082 Breathlessness Perceptions Within Respiratory Diseases
| NCT ID | NCT07648082 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospitals, Leicester |
| Condition | Chronic Obstructive Pulmonary Disease (COPD) |
| Study Type | OBSERVATIONAL |
| Enrollment | 75 participants |
| Start Date | 2025-06-06 |
| Primary Completion | 2026-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 75 participants in total. It began in 2025-06-06 with a primary completion date of 2026-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Breathlessness is a complex symptom that results in poor quality of life, increased hospitalisations and increased mortality. Breathlessness is influenced by physiological, psychological and functional factors but these are poorly explored. There are also unexplored phenomenon's such as breathing pattern. Therefore, this study aims to understand the influences of physiology, psychology, function and breathing pattern on health related quality of life in those with a respiratory disease compared to healthy controls. This project is a cross-sectional cohort study including those with a known respiratory disease and experiencing breathlessness, compared to non-breathless healthy controls. The investigators will measure your physiology through spirometry (a breathing test that tells us about their lung function), psychology through questionnaires, function through an exercise test and breathing pattern using opto-electrictronic plethysmography (markers are placed on your chest to see how participants breathe while exercising). This will be conducted over two visits. The investigators will recruit participants from clinics at the University Hospitals of Leicester NHS Trust. The investigators are aiming to recruit 50 participants with a respiratory disease and 25 healthy controls. The results of this study will help us understand breathlessness in more detail in order to be able to develop better treatments.
Eligibility Criteria
Inclusion Criteria: * • Aged 18 or over up to 100 * Known respiratory diagnosis\* OR Healthy control\*\* * Ongoing symptoms of breathlessness defined as ≥2 MRC dyspnoea scale * Able to communicate in English * Able to attend two study visits * Able to provide written informed consent * Known respiratory diagnosis could include, but is not limited to, COPD, Asthma, Bronchiectasis or ILD. * Healthy controls are required to have an absence of a functionally limiting condition such as respiratory, cardiovascular, or musculoskeletal. Exclusion Criteria: * • Unstable disease or undergoing investigations for unexplained symptoms * Undergone a surgery within past six weeks * Contraindications for exercise outlined by ACSM guidelines (Unstable CVD, hypertension etc) * BMI ≥ 35kg/m2 * Unable to communicate in English * Unable to provide written informed consent * Unable to abstain from smoking for 8 hours prior to testing
Contact & Investigator
Enya Daynes, PhD
PRINCIPAL INVESTIGATOR
University Hospitals, Leicester
Frequently Asked Questions
Who can join the NCT07648082 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Chronic Obstructive Pulmonary Disease (COPD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07648082 currently recruiting?
Yes, NCT07648082 is actively recruiting participants. Contact the research team at e.daynes@nhs.net for enrollment information.
Where is the NCT07648082 trial being conducted?
This trial is being conducted at Leicester, United Kingdom.
Who is sponsoring the NCT07648082 clinical trial?
NCT07648082 is sponsored by University Hospitals, Leicester. The principal investigator is Enya Daynes, PhD at University Hospitals, Leicester. The trial plans to enroll 75 participants.
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